Sleep-Disordered Breathing and Vascular Function in Patients With Chronic Mountain Sickness and Healthy High-Altitude Dwellers

被引:35
|
作者
Rexhaj, Emrush [1 ]
Rimoldi, Stefano F. [1 ]
Pratali, Lorenza [2 ]
Brenner, Roman [1 ]
Andries, Daniela [3 ]
Soria, Rodrigo [1 ]
Salinas, Carlos [5 ]
Villena, Mercedes [5 ]
Romero, Catherine [5 ]
Allemann, Yves [1 ]
Lovis, Alban [3 ]
Heinzer, Raphael [3 ]
Sartori, Claudio [1 ,4 ]
Scherrer, Urs [1 ,6 ]
机构
[1] Univ Bern, Inselspital, Dept Cardiol & Clin Res, CH-3010 Bern, Switzerland
[2] CNR, Inst Clin Physiol, Via Savi 8, I-56100 Pisa, Italy
[3] Lausanne CHUV, Ctr Invest & Res Sleep, Lausanne, Switzerland
[4] Lausanne CHUV, Dept Internal Med, Lausanne, Switzerland
[5] Inst Boliviano Biol Altura, La Paz, Bolivia
[6] Univ Tarapaca, Dept Biol, Fac Ciencias, Arica, Chile
基金
瑞士国家科学基金会;
关键词
chronic mountain sickness; high altitude; pulmonary artery pressure; sleep-disordered breathing; vascular function; PATENT FORAMEN OVALE; EXAGGERATED PULMONARY-HYPERTENSION; SYMPATHETIC-NERVE ACTIVITY; AIRWAY PRESSURE THERAPY; OXIDATIVE STRESS; DEAD SPACE; BLOOD-PRESSURE; HEART-FAILURE; EXCESSIVE ERYTHROCYTOSIS; INTERMITTENT HYPOXIA;
D O I
10.1378/chest.15-1450
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
BACKGROUND: Chronic mountain sickness (CMS) is often associated with vascular dysfunction, but the underlying mechanism is unknown. Sleep-disordered breathing (SDB) frequently occurs at high altitude. At low altitude, SDB causes vascular dysfunction. Moreover, in SDB, transient elevations of right-sided cardiac pressure may cause right-to-left shunting in the presence of a patent foramen ovale (PFO) and, in turn, further aggravate hypoxemia and pulmonary hypertension. We speculated that SDB and nocturnal hypoxemia are more pronounced in patients with CMS compared with healthy high-altitude dwellers, and are related to vascular dysfunction. METHODS: We performed overnight sleep recordings, and measured systemic and pulmonary artery pressure in 23 patients with CMS (mean +/- SD age, 52.8 +/- 9.8 y) and 12 healthy control subjects (47.8 +/- 7.8 y) at 3,600 m. In a subgroup of 15 subjects with SDB, we assessed the presence of a PFO with transesophageal echocardiography. RESULTS: The major new findings were that in patients with CMS, (1) SDB and nocturnal hypoxemia was more severe (P < .01) than in control subjects (apnea-hypopnea index [AHI], 38.9 +/- 25.5 vs 14.3 +/- 7.8 number of events per hour [nb/h]; arterial oxygen saturation, 80.2% +/- 3.6% vs 86.8% +/- 1.7%, CMS vs control group), and (2) AHI was directly correlated with systemic blood pressure (r = 0.5216; P = .001) and pulmonary artery pressure (r = 0.4497; P = .024). PFO was associated with more severe SDB (AHI, 48.8 +/- 24.7 vs 14.8 +/- 7.3 nb/h; P = .013, PFO vs no PFO) and hypoxemia. CONCLUSIONS: SDB and nocturnal hypoxemia are more severe in patients with CMS than in control subjects and are associated with systemic and pulmonary vascular dysfunction. The presence of a PFO appeared to further aggravate SDB. Closure of the PFO may improve SDB, hypoxemia, and vascular dysfunction in patients with CMS.
引用
收藏
页码:991 / 998
页数:8
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