Epithelial-Mesenchymal Transition and Its Regulation Mechanisms in Pancreatic Cancer

被引：28

作者：

Luu, Tuan ^{[1
]}

机构：

[1] Swinburne Univ Technol, Management & Mkt Dept, Hawthorn, Vic, Australia

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

epithelial-mesenchymal transition; pancreatic cancer; metastasis; EMT-regulating factors; EMT-regulating mechanisms; METASTASIS; CELLS; EMT;

D O I：

10.3389/fonc.2021.646399

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As one of the malignancies with high mortality and high insensitivity to existing therapies, pancreatic cancer and mechanisms underlying its progression have received growing scholarly attention. The role of the epithelial-mesenchymal transition (EMT) in pancreatic cancer genesis and metastasis has been reported albeit controversy has remained. Recent insights into further EMT-regulating mechanisms underlying pancreatic cancer contribute to the nexus between EMT and this cancer type. This review will elucidate the role of EMT as a hallmark for pancreatic cancer as well as summarize EMT-regulating factors recently detected as a key advance in the research stream on EMT in pancreatic cancer.

引用

页数：7

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