Increased trisomy 12 frequency and a biased IgVH 3-21 gene usage characterize small lymphocytic lymphoma

被引：15
作者：
Daudignon, Agnes [1 ]
Poulain, Stephanie [1 ]
Morel, Pierre [2 ]
Penther, Dominique [3 ]
Parmentier, Francoise [3 ]
Bouchindhomme, Brigitte [4 ]
Fernandes, Jose [5 ]
Duthilleul, Patrick [1 ]
Bastard, Christian [3 ]
机构：
[1] Ctr Hosp, Ctr Hematol Immunol Cytogenet, Valenciennes, France
[2] Ctr Hosp Schaffner, Serv Hematol Clin, Lens, France
[3] Ctr Lutte Contre Canc Henri Becquerel, Lab Genet Oncol, Rouen, France
[4] CHRU, Serv Anat & Cytol Pathol, Lille, France
[5] Ctr Hosp, Serv Hematol Clin, Valenciennes, France
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 05期
关键词：
Small lymphocytic lymphoma; VH3-21; Trisomy; 12; Deletion; 13q14; V-H MUTATION; SOMATIC HYPERMUTATION; PROGNOSTIC INDICATORS; GENOMIC ABERRATIONS; CD38; EXPRESSION; LEUKEMIA; SURVIVAL; SUBSET; LEVEL;
D O I：
10.1016/j.leukres.2009.11.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Small lymphocytic lymphoma (SLL) and chronic lymphocytic leukemia (CLL) are considered as similar entity by the WHO classification. We assessed the distribution of the four prognostic cytogenetic markers (deletion 11q23, 13q14, 17p13 and trisomy 12) and VH mutational status in 32 SLL and 119 CLL. Trisomy 12 was most frequent (36% vs 13%, p = 0.014) and 13q14 deletion was less frequent (9% vs 44%, p = 0.001) in SLL in comparison with CLL. An over representation of VH3-21 gene usage was found in SLL (17% vs 1%, p = 0.011). In conclusion, SLL show specific genetic markers that distinguish them from classical CLL. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：580 / 584
页数：5
相关论文
共 27 条
  • [1] Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma
    Aoun, P
    Blair, HE
    Smith, LM
    Dave, BJ
    Lynch, J
    Weisenburger, DD
    Pavletic, SZ
    Sanger, WG
    [J]. LEUKEMIA & LYMPHOMA, 2004, 45 (08) : 1595 - 1603
  • [2] Comparison of a quantitative PCR method with FISH for the assessment of the four aneuploidies commonly evaluated in CLL patients
    Bastard, C.
    Raux, G.
    Fruchart, C.
    Parmentier, F.
    Vaur, D.
    Penther, D.
    Troussard, X.
    Nagib, D.
    Lepretre, S.
    Tosi, M.
    Frebourg, T.
    Tilly, H.
    [J]. LEUKEMIA, 2007, 21 (07) : 1460 - 1463
  • [3] BINET JL, 1981, CANCER-AM CANCER SOC, V48, P198, DOI 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO
  • [4] 2-V
  • [5] Analysis of the human V-H gene repertoire - Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM(+) and CD5(-)/IgM(+) B cells
    Brezinschek, HP
    Foster, SJ
    Brezinschek, RI
    Dorner, T
    DomiatiSaad, R
    Lipsky, PE
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (10) : 2488 - 2501
  • [6] Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    Damle, RN
    Wasil, T
    Fais, F
    Ghiotto, F
    Valetto, A
    Allen, SL
    Buchbinder, A
    Budman, D
    Dittmar, K
    Kolitz, J
    Lichtman, SM
    Schulman, P
    Vinciguerra, VP
    Rai, KR
    Ferrarini, M
    Chiorazzi, N
    [J]. BLOOD, 1999, 94 (06) : 1840 - 1847
  • [7] Genomic aberrations and survival in chronic lymphocytic leukemia.
    Döhner, H
    Stilgenbauer, S
    Benner, A
    Leupolt, E
    Kröber, A
    Bullinger, L
    Döhner, K
    Bentz, M
    Lichter, P
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (26) : 1910 - 1916
  • [8] P53 GENE DELETION PREDICTS FOR POOR SURVIVAL AND NONRESPONSE TO THERAPY WITH PURINE ANALOGS IN CHRONIC B-CELL LEUKEMIAS
    DOHNER, H
    FISCHER, K
    BENTZ, M
    HANSEN, K
    BENNER, A
    CABOT, G
    DIEHL, D
    SCHLENK, R
    COY, J
    STILGENBAUER, S
    VOLKMANN, M
    GALLE, PR
    POUSTKA, A
    HUNSTEIN, W
    LICHTER, P
    [J]. BLOOD, 1995, 85 (06) : 1580 - 1589
  • [9] Chromosome aberrations in B-cell chronic lymphocytic leukemia:: reassessment based on molecular cytogenetic analysis
    Döhner, H
    Stilgenbauer, S
    Döhner, K
    Bentz, M
    Lichter, P
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 1999, 77 (02): : 266 - 281
  • [10] 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
    Dohner, H
    Stilgenbauer, S
    James, MR
    Benner, A
    Weilguni, T
    Bentz, M
    Fischer, K
    Hunstein, W
    Lichter, P
    [J]. BLOOD, 1997, 89 (07) : 2516 - 2522
123