A Comprehensive Review on Ulvan Based Hydrogel and Its Biomedical Applications

被引：33

作者：

Sulastri, Evi ^{[1
,2
]}

Lesmana, Ronny ^{[3
]}

Zubair, Muhammad Sulaiman ^{[2
]}

Elamin, Khaled M. ^{[4
]}

Wathoni, Nasrul ^{[1
]}

机构：

[1] Univ Padjadjaran, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Sumedang 45363, Indonesia

[2] Univ Tadulako, Dept Pharm, Fac Math & Nat Sci, Palu 94119, Indonesia

[3] Univ Padjadjaran, Dept Anat Physiol & Biol Cell, Fac OfAledicine, Sumedang 45363, Indonesia

[4] Kumamoto Univ, Fac Life Sci, Global Ctr Nat Resources Sci, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2021年 / 69卷 / 05期

关键词：

ulvan; green algae; hydrogel; biomedical application; MARINE-SULFATED POLYSACCHARIDES; WATER-SOLUBLE POLYSACCHARIDES; CELL-WALL POLYSACCHARIDES; RHEOLOGICAL PROPERTIES; FUNCTIONAL-PROPERTIES; CHEMICAL-COMPOSITION; MOLECULAR-WEIGHT; NMR ANALYSIS; LACTUCA L; ANTIOXIDANT;

D O I：

10.1248/cpb.c20-00763

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ulvan is a natural sulfated polysaccharide obtained from marine green algae composed of 3-sulfated rhamnoglucuronan as the main component. It has a unique chemical structure that rich of L-rhamnosa, D-glucuronic acid, and L-iduronic acid. Ulvan has a similar structure to glycosaminoglycans (GAGs) in mammals including chondroitin sulfate, dermatan sulfate, and heparan sulfate that has broad range applications for many years. Here, we provide an overview of ulvan based hydrogels for biomedical applications. Hydrogels are one of ulvan advances in polymer science for application in drug delivery, tissue engineering, and wound healing. This review presented an overview about functional information of ulvan based hydrogels and the promising potential in biomedicals collected from published papers in Scopus, PubMed, and Google Scholar. Other important aspects concerning properties, hydrogel-forming mechanisms, and ulvan based hydrogel developments were reported as well. As conclusion, ulvan showed interesting properties in forming hydrogels and promising advances in biomedical applications.

引用

页码：432 / 443

页数：12

共 134 条

[1]

Abd El-Baky H. H., 2008, J ENV AGR FOOD CHEM, V7, P3353

[2] Anticoagulant Activity of Sulfated Ulvan Isolated from the Green Macroalga Ulva rigida [J].