Amyloid angiopathy-related vascular cognitive impairment

被引：234
作者：
Greenberg, SA
Gurol, ME
Rosand, J
Smith, EE
机构：
[1] Massachusetts Gen Hosp, Neurol Clin Trials Unit, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
来源：
STROKE | 2004年 / 35卷 / 11期
关键词：
amyloid; angiopathy; vascular dementia;
D O I：
10.1161/01.str.0000143224.36527.44
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We review accumulating evidence that cerebrovascular amyloid deposition (cerebral amyloid angiopathy [CAA]) is an independent risk factor for cognitive dysfunction. The two population-based autopsy studies that have analyzed cognitive status during life as a function of CAA have each suggested deleterious effects of CAA on cognition even after controlling for age and Alzheimer disease pathology. We also review data from patients with CAA-related intracerebral hemorrhage (the one form of CAA that can be noninvasively recognized) suggesting associations of CAA with radiographic white matter abnormalities and cognitive impairment. These data highlight the importance of elucidating the effects of vascular amyloid on cerebrovascular function and of developing therapeutic strategies for this potentially widespread form of microvascular cognitive impairment.
引用
收藏
页码：2616 / 2619
页数：4
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