Hallmarks of gastrointestinal neuroendocrine tumours: implications for treatment

被引：41

作者：

Walenkamp, Annemiek ^{[1
]}

Crespo, Guillermo ^{[2
]}

Fierro Maya, Felipe ^{[3
]}

Fossmark, Reidar ^{[4
]}

Igaz, Peter ^{[5
]}

Rinke, Anja ^{[6
]}

Tamagno, Gianluca ^{[7
]}

Vitale, Giovanni ^{[8
,9
]}

Oberg, Kjell ^{[10
]}

Meyer, Tim ^{[11
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, NL-9713 GZ Groningen, Netherlands

[2] Hosp Univ Burgos, Dept Med Oncol, Burgos 09006, Spain

[3] Natl Canc Inst, Dept Endocrine Oncol, Bogota, Colombia

[4] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, N-7491 Trondheim, Norway

[5] Semmelweis Univ, Dept Med 2, H-1088 Budapest, Hungary

[6] Univ Hosp Marburg, Dept Gastroenterol, D-35043 Marburg, Germany

[7] St Columcilles Hosp, Dept Gen Internal Med, Dublin, Ireland

[8] Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy

[9] Ist Auxol Italiano IRCCS, Lab Endocrine & Metab Res, I-20095 Cusano Milanino, MI, Italy

[10] Univ Hosp, Dept Endocrine Oncol, Uppsala, Sweden

[11] UCL, Inst Canc, London WC1E 6BT, England

来源：

关键词：

cancer; neuroendocrine tumours; treatment; tumourigenesis; ENDOTHELIAL GROWTH-FACTOR; PANCREATIC ENDOCRINE TUMORS; SOMATOSTATIN RECEPTOR BIOLOGY; PROTEIN-COUPLED RECEPTORS; REGULATORY T-CELLS; PHASE-II; TELOMERASE ACTIVITY; CARCINOID-TUMORS; MTOR PATHWAY; MICROSATELLITE INSTABILITY;

D O I：

10.1530/ERC-14-0106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the past few years, there have been advances in the treatment of neuroendocrine tumours (NETs) and improvements in our understanding of NET biology. However, the benefits to patients have been relatively modest and much remains yet to be done. The 'Hallmarks of Cancer', as defined by Hanahan and Weinberg, provide a conceptual framework for understanding the aberrations that underlie tumourigenesis and to help identify potential targets for therapy. In this study, our objective is to review the major molecular characteristics of NETs, based on the recently modified 'Hallmarks of Cancer', and highlight areas that require further research.

引用

页码：R445 / R460

页数：16

共 151 条

[1] Uncovering the mechanisms that regulate tumor-induced T-cell anergy [J].