Asparagine endopeptidase cleaves tau and promotes neurodegeneration

被引：9

作者：

Rosenmann, Hanna ^{[1
]}

机构：

[1] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel

来源：

NATURE MEDICINE | 2014年 / 20卷 / 11期

关键词：

ALZHEIMERS-DISEASE; MECHANISM; TANGLES; BRAIN;

D O I：

10.1038/nm.3749

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Truncation of tau contributes to the formation of neurofibrillary tangles in Alzheimer's disease. A new study finds a direct role for a lysosomal cysteine protease, asparagine endopeptidase, in cleaving tau into neurotoxic fragments.

引用

页码：1236 / 1238

页数：3

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