Antimycobacterial activity of usnic acid against resistant and susceptible strains of Mycobacterium tuberculosis and non-tuberculous mycobacteria

被引：38

作者：

Ramos, Daniela Fernandes ^{[1
,2
]}

Almeida da Silva, Pedro Eduardo ^{[1
,2
]}

机构：

[1] Fundacao Univ Fed Rio Grande, Programa Posgrad Ciencias Saude, Rio Grande, Brazil

[2] Univ Fed, Lab Micobacteriol Rio Grande, FURG, Rio Grande, Brazil

来源：

PHARMACEUTICAL BIOLOGY | 2010年 / 48卷 / 03期

关键词：

Usnic acid; Mycobacterium tuberculosis; nontuberculous mycobacteria; resistance; efflux; METABOLITES;

D O I：

10.3109/13880200903085490

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Tuberculosis remains a serious public health problem, with nine million cases being reported annually. Treatment with antibiotics is the most effective mechanism to control this disease, although the increase in cases with resistant strains, co-infection with HIV, and the long duration of treatment has established the need to develop new drugs. Here we show the activity of usnic acid against susceptible and resistant Mycobacterium tuberculosis strains and against nontuberculous mycobacteria. Further, we did not identify any contribution of efflux in innate resistance to usnic acid.</.

引用

页码：260 / 263

页数：4

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