Massively parallel functional photoacoustic computed tomography of the human brain

被引：156

作者：

Na, Shuai ^{[1
]}

Russin, Jonathan J. ^{[2
,3
,4
]}

Lin, Li ^{[1
]}

Yuan, Xiaoyun ^{[1
,7
]}

Hu, Peng ^{[1
]}

Jann, Kay B. ^{[5
]}

Yan, Lirong ^{[5
]}

Maslov, Konstantin ^{[1
]}

Shi, Junhui ^{[1
,8
]}

Wang, Danny J. ^{[5
]}

Liu, Charles Y. ^{[2
,3
,4
]}

Wang, Lihong, V ^{[1
,6
]}

机构：

[1] CALTECH, Andrew & Peggy Cherng Dept Med Engn, Caltech Opt Imaging Lab, Pasadena, CA 91125 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Neurol Surg, Los Angeles, CA 90007 USA

[3] Univ Southern Calif, Neurorestorat Ctr, Keck Sch Med, Los Angeles, CA 90007 USA

[4] Rancho Amigos Natl Rehabil Ctr, Downey, CA 90242 USA

[5] Univ Southern Calif, Keck Sch Med, Stevens Neuroimaging & Informat Inst, Lab Funct MRI Technol, Los Angeles, CA 90007 USA

[6] CALTECH, Dept Elect Engn, Caltech Opt Imaging Lab, Pasadena, CA 91125 USA

[7] Tsinghua Univ, Dept Elect Engn, Beijing, Peoples R China

[8] Zhejiang Lab, Hangzhou, Peoples R China

来源：

NATURE BIOMEDICAL ENGINEERING | 2022年 / 6卷 / 05期

基金：

美国国家卫生研究院;

关键词：

HIGH-RESOLUTION; LANGUAGE; CORTEX; FMRI; AREA;

D O I：

10.1038/s41551-021-00735-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging of the human brain requires bulky equipment for the generation of magnetic fields. Photoacoustic computed tomography obviates the need for magnetic fields by using light and sound to measure deoxyhaemoglobin and oxyhaemoglobin concentrations to then quantify oxygen saturation and blood volumes. Yet, the available imaging speeds, fields of view (FOV), sensitivities and penetration depths have been insufficient for functional imaging of the human brain. Here, we show that massively parallel ultrasonic transducers arranged hemispherically around the human head can produce tomographic images of the brain with a 10-cm-diameter FOV and spatial and temporal resolutions of 350 mu m and 2 s, respectively. In patients who had a hemicraniectomy, a comparison of functional photoacoustic computed tomography and 7 T BOLD functional magnetic resonance imaging showed a strong spatial correspondence in the same FOV and a high temporal correlation between BOLD signals and photoacoustic signals, with the latter enabling faster detection of functional activation. Our findings establish the use of photoacoustic computed tomography for human brain imaging. Massively parallel ultrasonic transducers arranged hemispherically around the human head enable functional photoacoustic computed tomography of the human brain with a 10-cm-diameter field of view and resolutions of 350 mu m and 2 s.

引用

页码：584 / 592

页数：9

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