A neglected demented patient was treated for neovascular glaucoma (NVG) and orbital cellulitis and was later given the diagnosis of uveal melanoma. Histologically, the tumor extensively infiltrated the sclera, causing massive scleral destruction and invasion of the orbit Preliminary invasion of scleral emissaries was not identified. Investigative imaging is important early in the course of NVG in patients with opaque media, especially in the demented population.