Evaluation of the radiochemical impurities arising during the competitive fluorination of nosyl group during the synthesis of 3′-deoxy-3′-fluorothymidine, [18F]FLT

被引：7

作者：

Nandy, S. K. ^{[1
]}

Krishnamurthy, N. V. ^{[2
]}

Rajan, M. G. R. ^{[1
]}

机构：

[1] Tata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, India

[2] Tata Mem Hosp Annexe, Dept Atom Energy, Med Cyclotron Facil, Board Radiat & Isotope Technol, Mumbai 400012, Maharashtra, India

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2010年 / 283卷 / 01期

关键词：

F-18]FLT; FLT-synthesis; Nosyl fluoride; Radiofluorination; POSITRON-EMISSION-TOMOGRAPHY; PROLIFERATION IN-VIVO; NUCLEOPHILIC DISPLACEMENT; NITRO-GROUPS; 3'-FLUORO-3'-DEOXYTHYMIDINE; RADIOSYNTHESIS; SUBSTITUTION; FLUORIDES; PRECURSOR;

D O I：

10.1007/s10967-009-0322-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The study is aimed at the analysis and identification of radiochemical and chemical impurities present in [F-18]FLT synthesized by a simplified combination-column purification procedure, instead of the currently used HPLC purification. HPLC analysis of the final product showed an anionic radioactive byproduct, which was established as [F-18]4-FBSA. The identity of the product was also confirmed by the radiofluorination of nosyl chloride. Mass spectrum analysis of both a decayed sample of [F-18]FLT and fluorinated nosyl chloride showed a major peak at 242. We have also investigated the possible interference of this byproduct during PET-imaging in rabbits.

引用

页码：245 / 251

页数：7

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