An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice

被引：32

作者：

Massilamany, Chandirasegaran ^{[1
]}

Steffen, David ^{[1
]}

Reddy, Jay ^{[1
]}

机构：

[1] Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 219卷 / 1-2期

关键词：

Experimental autoimmune encephalomyelitis; Multiple sclerosis; Molecular mimicry; Proteolipid protein; Acanthamoeba castellanii; Acanthamoeba granulomatous encephalitis; MYELIN BASIC-PROTEIN; CENTRAL-NERVOUS-SYSTEM; MOLECULAR MIMICRY; OLIGODENDROCYTE GLYCOPROTEIN; MULTIPLE-SCLEROSIS; VIRAL PEPTIDE; LIMITED HOMOLOGY; T-H-17; CELLS; DISEASE; LYMPHOCYTES;

D O I：

10.1016/j.jneuroim.2009.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report here that an epitope (aa, 83-95) derived from Acanthamoeba castellanii (ACA) induces clinical signs of experimental autoimmune encephalomyelitis (EAE) in SJL/J mice reminiscent of the disease Induced with myelin proteolipid protein (PLP) 139-151 By using IA(s)/tetramers. we demonstrate that both ACA 83-95 and PLP 139-151 generate anti.-en-specific cross-reactive CD4 T cells and the T cells secrete identical patterns of cytokines and induce EAE with a similar seventy. These results may provide insights into the pathogenesis of multiple sclerosis and ACA-induced granulomatous encephalitis (C) 2009 Elsevier B V. All rights reserved

引用

页码：17 / 24

页数：8

共 36 条

[1] High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire [J].

Anderson, AC ;

Nicholson, LB ;

Legge, KL ;

Turchin, V ;

Zaghouani, H ;

Kuchroo, VK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (05) :761-770

[2] CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE [J].

Bailey, Samantha L. ;

Schreiner, Bettina ;

McMahon, Eileen J. ;

Miller, Stephen D. .

NATURE IMMUNOLOGY, 2007, 8 (02) :172-180

[3] TH-17 cells in the circle of immunity and autoimmunity [J].

Bettelli, Estelle ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2007, 8 (04) :345-350

[4] INDUCTION OF RELAPSING PARALYSIS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY BACTERIAL SUPERANTIGEN [J].

BROCKE, S ;

GAUR, A ;

PIERCY, C ;

GAUTAM, A ;

GIJBELS, K ;

FATHMAN, CG ;

STEINMAN, L .

NATURE, 1993, 365 (6447) :642-644

[5]

Carrizosa AM, 1998, J IMMUNOL, V161, P3307

[6]

Claerhout I, 1999, Bull Soc Belge Ophtalmol, V274, P71

[7] MHC class II peptide flanking residues of exogenous antigens influence recognition by-autoreactive T cells [J].

Conant, SB ;

Swanborg, RH .

AUTOIMMUNITY REVIEWS, 2003, 2 (01) :8-12

[8] Viral delivery of an epitope from Haemophilus influenzae induces central nervous system autoimmune disease by molecular mimicry [J].

Croxford, JL ;

Anger, HA ;

Miller, SD .

JOURNAL OF IMMUNOLOGY, 2005, 174 (02) :907-917

[9] REACTIVITY TO MYELIN ANTIGENS IN MULTIPLE-SCLEROSIS - PERIPHERAL-BLOOD LYMPHOCYTES RESPOND PREDOMINANTLY TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN [J].

DEROSBO, NK ;

MILO, R ;

LEES, MB ;

BURGER, D ;

BERNARD, CCA ;

BENNUN, A .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (06) :2602-2608

[10] Role of immunologic cross-reactivity in neurological diseases [J].

Ercolini, AM ;

Miller, SD .

NEUROLOGICAL RESEARCH, 2005, 27 (07) :726-733

← 1 2 3 4 →