Pleomorphic Liposarcoma: A Cytologic Study of Five Cases

被引:10
作者
Dodd, Leslie G. [1 ]
Jiang, Xiaoyin Sara [2 ]
Rao, Kathleen [1 ,3 ]
Bui, Marilyn M. [4 ]
机构
[1] Univ N Carolina, Dept Pathol, Chapel Hill, NC 27514 USA
[2] Duke Univ Hlth Syst, Dept Pathol, Durham, NC USA
[3] Univ N Carolina, Dept Pediat, Chapel Hill, NC 27514 USA
[4] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Anat Pathol, Tampa, FL 33682 USA
关键词
pleomorphic liposarcoma; liposarcoma; fine needle aspiration; NEEDLE-ASPIRATION BIOPSY; EPITHELIOID VARIANT; CLINICOPATHOLOGICAL ANALYSIS; EXTREMITY; DIAGNOSIS; FEATURES; TARGETS;
D O I
10.1002/dc.23148
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Pleomorphic liposarcoma represents one of the rarest variants of liposarcoma. It has a poor prognosis and unlike other variants of liposarcoma, lacks a molecular or genetic signature. Histologic studies of pleomorphic liposarcoma have defined this lesion as a high grade sarcoma, which contains a variable number of lipoblasts. We describe the cytologic features of five cases of pleomorphic liposarcoma, all of which had histologic confirmation. We consistently identified numerous lipoblasts as well as micro and macrovesicular fat vacuoles in the background of cellular, pleomorphic sarcomatoid neoplasms. The appearance of the aspirates differs substantially form other variants of liposarcoma. Diagn. Cytopathol. 2015;43:138-143. (c) 2014 Wiley Periodicals, Inc.
引用
收藏
页码:138 / 143
页数:6
相关论文
共 44 条
[1]   Intrathoracic pleomorphic liposarcoma in a child: Study of an unusual case [J].
Ali, SZ ;
Teichberg, S ;
Kahn, E ;
Hajdu, SI .
PEDIATRIC PATHOLOGY & LABORATORY MEDICINE, 1996, 16 (01) :99-105
[2]   Cytopathological Diagnosis of Metastatic Pleomorphic Liposarcoma in the Lung: A Report of a Case Correlated With The Histopathology of the Primary Tumour [J].
Apostolou, George ;
Biteli, Maria ;
Chatzipantelis, Paschalis .
DIAGNOSTIC CYTOPATHOLOGY, 2009, 37 (09) :667-670
[3]   eComment: Primary pleomorphic liposarcoma: a rare mediastinal tumor [J].
Barbetakis, Nikolaos ;
Asteriou, Christos ;
Kleontas, Athanassios ;
Karvelas, Christos .
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 2010, 11 (03) :327-327
[4]   Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy [J].
Barretina, Jordi ;
Taylor, Barry S. ;
Banerji, Shantanu ;
Ramos, Alexis H. ;
Lagos-Quintana, Mariana ;
DeCarolis, Penelope L. ;
Shah, Kinjal ;
Socci, Nicholas D. ;
Weir, Barbara A. ;
Ho, Alan ;
Chiang, Derek Y. ;
Reva, Boris ;
Mermel, Craig H. ;
Getz, Gad ;
Antipin, Yevgenyi ;
Beroukhim, Rameen ;
Major, John E. ;
Hatton, Charles ;
Nicoletti, Richard ;
Hanna, Megan ;
Sharpe, Ted ;
Fennell, Tim J. ;
Cibulskis, Kristian ;
Onofrio, Robert C. ;
Saito, Tsuyoshi ;
Shukla, Neerav ;
Lau, Christopher ;
Nelander, Sven ;
Silver, Serena J. ;
Sougnez, Carrie ;
Viale, Agnes ;
Winckler, Wendy ;
Maki, Robert G. ;
Garraway, Levi A. ;
Lash, Alex ;
Greulich, Heidi ;
Root, David E. ;
Sellers, William R. ;
Schwartz, Gary K. ;
Antonescu, Cristina R. ;
Lander, Eric S. ;
Varmus, Harold E. ;
Ladanyi, Marc ;
Sander, Chris ;
Meyerson, Matthew ;
Singer, Samuel .
NATURE GENETICS, 2010, 42 (08) :715-U103
[5]   Primary pleomorphic liposarcoma of the parotid gland: A case report and review of the literature [J].
Chandan, VS ;
Fung, EK ;
Woods, CI ;
de La Roza, G .
AMERICAN JOURNAL OF OTOLARYNGOLOGY, 2004, 25 (06) :432-437
[6]  
CHANG HR, 1989, CANCER-AM CANCER SOC, V64, P1514, DOI 10.1002/1097-0142(19891001)64:7<1514::AID-CNCR2820640726>3.0.CO
[7]  
2-2
[8]   Pathology quiz case 2: Pleomorphic liposarcoma (PLS) of the retrotonsillar fossa [J].
Chute, Deborah J. ;
Shutter, Jamie ;
Mills, Stacey E. .
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2007, 133 (03) :303-+
[9]  
Conyers Rachel, 2011, Sarcoma, V2011, P483154, DOI 10.1155/2011/483154
[10]   Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk [J].
Dalal, Kimberly Moore ;
Kattan, Michael W. ;
Antonescu, Cristina R. ;
Brennan, Murray F. ;
Singer, Samuel .
ANNALS OF SURGERY, 2006, 244 (03) :381-391