Radiation and Thyroid Cancer

被引：93

作者：

Albi, Elisabetta ^{[1
]}

Cataldi, Samuela ^{[1
]}

Lazzarini, Andrea ^{[2
]}

Codini, Michela ^{[1
]}

Beccari, Tommaso ^{[1
]}

Ambesi-Impiombato, Francesco Saverio ^{[3
]}

Curcio, Francesco ^{[3
]}

机构：

[1] Univ Perugia, Dept Pharmaceut Sci, I-06123 Perugia, Italy

[2] Res Ctr & Anal Lab CRABiON, I-06073 Perugia, Italy

[3] Univ Udine, Dept Clin & Biol Sci, I-33100 Udine, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 05期

关键词：

radiation; thyroid cancer; cancer genes; lipid metabolism; PERIPHERAL-BLOOD LYMPHOCYTES; NUCLEAR LIPID MICRODOMAIN; JUN NH2-TERMINAL KINASE; IONIZING-RADIATION; POST-CHERNOBYL; ULTRAVIOLET-RADIATION; MICRONUCLEI FREQUENCY; DEPENDENT APOPTOSIS; INDUCED ACTIVATION; GAMMA-RADIATION;

D O I：

10.3390/ijms18050911

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Radiation-induced damage is a complex network of interlinked signaling pathways, which may result in apoptosis, cell cycle arrest, DNA repair, and cancer. The development of thyroid cancer in response to radiation, from nuclear catastrophes to chemotherapy, has long been an object of study. A basic overview of the ionizing and non-ionizing radiation effects of the sensitivity of the thyroid gland on radiation and cancer development has been provided. In this review, we focus our attention on experiments in cell cultures exposed to ionizing radiation, ultraviolet light, and proton beams. Studies on the involvement of specific genes, proteins, and lipids are also reported. This review also describes how lipids are regulated in response to the radiation-induced damage and how they are involved in thyroid cancer etiology, invasion, and migration and how they can be used as both diagnostic markers and drug targets.

引用

页数：11

共 79 条

[1] The nuclear ceramide/diacylglycerol balance depends on the physiological state of thyroid cells and changes during UV-C radiation-induced apoptosis [J].