Hierarchical organization of cortical and thalamic connectivity

被引：392

作者：

Harris, Julie A. ^{[1
]}

Mihalas, Stefan ^{[1
]}

Hirokawa, Karla E. ^{[1
]}

Whitesell, Jennifer D. ^{[1
]}

Choi, Hannah ^{[1
,2
]}

Bernard, Amy ^{[1
]}

Bohn, Phillip ^{[1
]}

Caldejon, Shiella ^{[1
]}

Casal, Linzy ^{[1
]}

Cho, Andrew ^{[1
]}

Feiner, Aaron ^{[1
]}

Feng, David ^{[1
]}

Gaudreault, Nathalie ^{[1
]}

Gerfen, Charles R. ^{[3
]}

Graddis, Nile ^{[1
]}

Groblewski, Peter A. ^{[1
]}

Henry, Alex M. ^{[1
]}

Ho, Anh ^{[1
]}

Howard, Robert ^{[1
]}

Knox, Joseph E. ^{[1
]}

Kuan, Leonard ^{[1
]}

Kuang, Xiuli ^{[4
]}

Lecoq, Jerome ^{[1
]}

Lesnar, Phil ^{[1
]}

Li, Yaoyao ^{[4
]}

Luviano, Jennifer ^{[1
]}

McConoughey, Stephen ^{[1
]}

Mortrud, Marty T. ^{[1
]}

Naeemi, Maitham ^{[1
]}

Ng, Lydia ^{[1
]}

Oh, Seung Wook ^{[1
]}

Ouellette, Benjamin ^{[1
]}

Shen, Elise ^{[1
]}

Sorensen, Staci A. ^{[1
]}

Wakeman, Wayne ^{[1
]}

Wang, Quanxin ^{[1
]}

Wang, Yun ^{[1
]}

Williford, Ali ^{[1
]}

Phillips, John W. ^{[1
]}

Jones, Allan R. ^{[1
]}

Koch, Christof ^{[1
]}

Zeng, Hongkui ^{[1
]}

机构：

[1] Allen Inst Brain Sci, Seattle, WA 98109 USA

[2] Univ Washington, Dept Appl Math, Seattle, WA 98195 USA

[3] NIMH, Lab Syst Neurosci, Bethesda, MD 20892 USA

[4] Wenzhou Med Univ, Wenzhou, Peoples R China

来源：

NATURE | 2019年 / 575卷 / 7781期

基金：

美国国家卫生研究院;

关键词：

CRE-RECOMBINASE; MOUSE; CONNECTOME; PROJECTIONS; CIRCUIT; TOMOGRAPHY; NETWORKS; DRIVER; CORTEX; LINES;

D O I：

10.1038/s41586-019-1716-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mammalian cortex is a laminar structure containing many areas and cell types that are densely interconnected in complex ways, and for which generalizable principles of organization remain mostly unknown. Here we describe a major expansion of the Allen Mouse Brain Connectivity Atlas resource(1), involving around a thousand new tracer experiments in the cortex and its main satellite structure, the thalamus. We used Cre driver lines (mice expressing Cre recombinase) to comprehensively and selectively label brain-wide connections by layer and class of projection neuron. Through observations of axon termination patterns, we have derived a set of generalized anatomical rules to describe corticocortical, thalamocortical and corticothalamic projections. We have built a model to assign connection patterns between areas as either feedforward or feedback, and generated testable predictions of hierarchical positions for individual cortical and thalamic areas and for cortical network modules. Our results show that cell-class-specific connections are organized in a shallow hierarchy within the mouse corticothalamic network.

引用

页码：195 / +

页数：27

共 60 条

[1]

Bastian M., 2009, P INT AAAI C WEB SOC, V3, P361, DOI [10.1609/icwsm.v3i1.13937, DOI 10.1609/ICWSM.V3I1.13937, 10.13140/2.1.1341.1520]

[2] Fast unfolding of communities in large networks [J].