Targeting cell-cycle machinery in cancer

被引：402

作者：

Suski, Jan M. ^{[1
,2
]}

Braun, Marcin ^{[1
,2
,3
]}

Strmiska, Vladislav ^{[1
,2
]}

Sicinski, Piotr ^{[1
,2
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA

[2] Harvard Med Sch, Blavatnik Inst, Dept Genet, Boston, MA 02115 USA

[3] Med Univ Lodz, Dept Pathol, Chair Oncol, PL-92213 Lodz, Poland

来源：

CANCER CELL | 2021年 / 39卷 / 06期

关键词：

DEPENDENT KINASE 2; INHIBITOR DINACICLIB MK-7965; BREAST-CANCER; T-CELL; CDK4/6; INHIBITION; INDEPENDENT FUNCTION; CDK2; SYNTHETICALLY LETHAL; ANTITUMOR-ACTIVITY; INDUCED SENESCENCE;

D O I：

10.1016/j.ccell.2021.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abnormal activity of the core cell-cyclemachinery is seen in essentially all tumor types and represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins regulate a wide range of cellular functions, in addition to promoting cell division. With the clinical success of CDK4/6 inhibitors, it is becoming increasingly clear that targeting individual cell-cycle components may represent an effective anti-cancer strategy. Here, we discuss the potential of inhibiting different cell-cycle proteins for cancer therapy.

引用

页码：759 / 778

页数：20

共 167 条

[1] Expression of cyclins A and D and p21(waf1/cip1) proteins in renal cell cancer and their relation to clinicopathological variables and patient survival [J].

Aaltomaa, S ;

Lipponen, P ;

Ala-Opas, M ;

Eskelinen, M ;

Syrjänen, K ;

Kosma, VM .

BRITISH JOURNAL OF CANCER, 1999, 80 (12) :2001-2007

[2] Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin E [J].

Akli, Said ;

Van Pelt, Carolyn S. ;

Bui, Tuyen ;

Meijer, Laurent ;

Keyomarsi, Khandan .

CANCER RESEARCH, 2011, 71 (09) :3377-3386

[3] The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity [J].

Ali, Simak ;

Heathcote, Dean A. ;

Kroll, Sebastian H. B. ;

Jogalekar, Ashutosh S. ;

Scheiper, Bodo ;

Patel, Hetal ;

Brackow, Jan ;

Siwicka, Alekasandra ;

Fuchter, Matthew J. ;

Periyasamy, Manikandan ;

Tolhurst, Robert S. ;

Kanneganti, Seshu K. ;

Snyder, James P. ;

Liotta, Dennis C. ;

Aboagye, Eric O. ;

Barrett, Anthony G. M. ;

Coombes, R. Charles .

CANCER RESEARCH, 2009, 69 (15) :6208-6215

[4] Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition [J].

Alvarez-Fernandez, Monica ;

Malumbres, Marcos .

CANCER CELL, 2020, 37 (04) :514-529

[5] A novel function for Cyclin A2: Control of cell invasion via RhoA signaling [J].

Arsic, Nikola ;

Bendris, Nawal ;

Peter, Marion ;

Begon-Pescia, Christina ;

Rebouissou, Cosette ;

Gadea, Gilles ;

Bouquier, Nathalie ;

Bibeau, Frederic ;

Lemmers, Benedicte ;

Blanchard, Jean Marie .

JOURNAL OF CELL BIOLOGY, 2012, 196 (01) :147-162

[6] The history and future of targeting cyclin-dependent kinases in cancer therapy [J].

Asghar, Uzma ;

Witkiewicz, Agnieszka K. ;

Turner, Nicholas C. ;

Knudsen, Erik S. .

NATURE REVIEWS DRUG DISCOVERY, 2015, 14 (02) :130-146

[7] Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition [J].

Au-Yeung, George ;

Lang, Franziska ;

Azar, Walid J. ;

Mitchell, Chris ;

Jarman, Kate E. ;

Lackovic, Kurt ;

Aziz, Diar ;

Cullinane, Carleen ;

Pearson, Richard B. ;

Mileshkin, Linda ;

Rischin, Danny ;

Karst, Alison M. ;

Drapkin, Ronny ;

Etemadmoghadam, Dariush ;

Bowtell, David D. L. .

CLINICAL CANCER RESEARCH, 2017, 23 (07) :1862-1874

[8] Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors [J].

Azimi, Alireza ;

Caramuta, Stefano ;

Seashore-Ludlow, Brinton ;

Bostrom, Johan ;

Robinson, Jonathan L. ;

Edfors, Fredrik ;

Tuominen, Rainer ;

Kemper, Kristel ;

Krijgsman, Oscar ;

Peeper, Daniel S. ;

Nielsen, Jens ;

Hansson, Johan ;

Brage, Suzanne Egyhazi ;

Altun, Mikael ;

Uhlen, Mathias ;

Maddalo, Gianluca .

MOLECULAR SYSTEMS BIOLOGY, 2018, 14 (03)

[9] Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress [J].

Bayard, Quentin ;

Meunier, Lea ;

Peneau, Camille ;

Renault, Victor ;

Shinde, Jayendra ;

Nault, Jean-Charles ;

Mami, Iadh ;

Couchy, Gabrielle ;

Amaddeo, Giuliana ;

Tubacher, Emmanuel ;

Bacq, Delphine ;

Meyer, Vincent ;

La Bella, Tiziana ;

Debaillon-Vesque, Audrey ;

Bioulac-Sage, Paulette ;

Seror, Olivier ;

Blanc, Jean-Frederic ;

Calderaro, Julien ;

Deleuze, Jean-Francois ;

Imbeaud, Sandrine ;

Zucman-Rossi, Jessica ;

Letouze, Eric .

NATURE COMMUNICATIONS, 2018, 9

[10] Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer [J].

Beale, Gary ;

Haagensen, Emma J. ;

Thomas, Huw D. ;

Wang, Lan-Zhen ;

Revill, Charlotte H. ;

Payne, Sara L. ;

Golding, Bernard T. ;

Hardcastle, Ian R. ;

Newell, David R. ;

Griffin, Roger J. ;

Cano, Celine .

BRITISH JOURNAL OF CANCER, 2016, 115 (06) :682-690

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