Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: The significance of extracapsular spread and soft tissue deposits

被引：73
作者：
Jose, J
Coatesworth, AP
Johnston, C
MacLennan, K
机构：
[1] St James Univ Hosp, Ctr Clin Canc, Canc Res UK, Leeds LS9 7TF, W Yorkshire, England
[2] Leeds Gen Infirm, Dept Otolaryngol Head & Neck Surg, Leeds, W Yorkshire, England
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2003年 / 25卷 / 06期
关键词：
carcinoma; squamous cell; head and neck neoplasms; lymphatic metastasis; prognosis;
D O I：
10.1002/hed.10214
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. Literature regarding the prognostic significance of extracapsular spread and soft tissue deposits in cervical lymph node metastases of squamous cell carcinoma of the upper aerodigestive tract shows variable results. Methods. We analyzed 215 prospectively collected neck dissections from 155 patients with upper aerodigestive tract squamous cell carcinoma to assess the prevalence of extracapsular spread and soft tissue deposits and to assess their effect on survival. Results. Both extracapsular spread and soft tissue deposits significantly reduced survival (actuarial and recurrence free) compared with pN0 necks (p <.001) and pN+ve necks without extracapsular spread (p <.0025). There was no statistically significant difference between pN+ve necks without soft tissue deposits or extracapsular spread compared with those with pN0 necks (p =.24). Multivariate analysis revealed comparable results. Conclusions. Microscopic and macroscopic extracapsular spread and soft tissue deposits are of prognostic significance for survival and recurrence-free survival in patients with upper aerodigestive tract squamous cell carcinoma. (C) 2003 Wiley Periodicals, Inc.
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收藏
页码：451 / 456
页数：6
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