An Integrative Tool for Gene Regulatory Network Reconstruction Based on Microarray Data

被引：0

作者：

Ou, J. W. ^{[1
]}

Tang, C. Y. ^{[1
]}

Chen, R. M. ^{[2
]}

Hu, R. M. ^{[3
]}

Tsai, Jeffrey J. P. ^{[4
]}

机构：

[1] Natl Tsing Hua Univ, Dept Comp Sci, Hsinchu 30043, Taiwan

[2] Natl Univ Tainan, Dept Comp Sci & Informat Engn, Tainan, Taiwan

[3] Asia Univ, Dept Biotechnol, Taichung, Taiwan

[4] Univ Illinois, Dept Comp Sci, Chicago, IL USA

来源：

2009 9TH IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING | 2009年

关键词：

gene regulatory network; network component analysis; microarray data; transcription factor;

D O I：

10.1109/BIBE.2009.44

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The transcriptional regulation of gene expression has been known to be a key mechanism in the functioning of the cell and the gene expression is influenced by the transcriptional regulatory strengths. In this paper we extend the function of a former proposed gene expression analysis tool named Gene Expression Explorer to include the gene regulatory network reconstruction based on microarray data. The regulatory strengths between transcription factors and genes are implemented by a modified network component analysis method where the genes expression relationships between genes vs. tissues and transcription factors vs. tissues are adopted to explore the regulatory strengths between genes and various transcription factors. Visualized presentation of the proposed tool clearly illustrates the regulatory patterns of transcription factors for each related gene. The biologists could benefit from using this tool to analyze the gene regulatory network based on microarray data.

引用

页码：467 / 470

页数：4

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