The role of CGRP and CALCA T-692C single-nucleotide polymorphism in psoriasis vulgaris

被引:14
作者
Guo, Ren [3 ]
Li, Fang-Fang [2 ]
Chen, Ming-Liang [2 ]
Yao, Ming-Zhu [2 ]
He, Hui-Lan [2 ]
Li, Dai [1 ,2 ]
机构
[1] Cent S Univ, Xiangya Hosp, Natl Inst Drug Clin Trial, Changsha, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp 3, Dept Pharm, Changsha, Hunan, Peoples R China
来源
PHARMAZIE | 2015年 / 70卷 / 02期
基金
美国国家科学基金会; 中国博士后科学基金;
关键词
GENE-RELATED PEPTIDE; NEUROGENIC INFLAMMATION; ASSOCIATION; SKIN; NEUROPEPTIDES; IMMUNOREACTIVITY; HYPERTENSION; STIMULATION; EXPRESSION; RELEASE;
D O I
10.1691/ph.2015.4722
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Calcitonin gene related protein (CGRP) is increased in both lesional and non-lesional psoriasis. The role of CGRP in the pathogenesis of psoriasis vulgaris is still not clear. We designed to determine the CGRP-I (or CALCA), II (or CALCB) gene expression and morbidity and CALCA T-692C single-nucleotide polymorphism (SNP). Peripheral blood mononuclear cells (PBMCs) and plasma samples were collected, and CGRP level and CGRP-I, II mRNA expression were measured in psoriasis patients and healthy controls. The CALCA T-692C genetic polymorphism in psoriasis and control subjects was also compared. A higher expression of CGRP-I, II mRNA in PBMCs in psoriasis patients. The plasma CGRP level in psoriasis patients was also higher than that in healthy subjects. SNP analysis showed carriers of the T-692C allele were over-represented in non-drinking Patients. The plasma CGRP level was higher in alcohol-drinking patients with TT genotype than that with TC genotype. The plasma CGRP level is increased in psoriasis patients and CALCA T-692C polymorphism TT genotype is a factor for the affectability in alcohol-drinking Psoriasis vulgaris patients.
引用
收藏
页码:88 / 93
页数:6
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