Forkhead-box transcription factors and their role in the immune system

被引：324
作者：
Coffer, PJ
Burgering, BMT
机构：
[1] Univ Med Ctr, Dept Pulm Dis, NL-3584 CX Utrecht, Netherlands
[2] Univ Med Ctr, Dept Physiol Chem, NL-3584 CX Utrecht, Netherlands
来源：
NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 11期
关键词：
D O I：
10.1038/nri1488
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening time, there has been an explosion in the identification and characterization of members of this family of proteins. Importantly, in the past few years, it has become clear that members of the FOX family have crucial roles in various aspects of immune regulation, from lymphocyte survival to thymic development. This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.
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收藏
页码：889 / 899
页数：11
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