PBTK modeling of potential endocrine modulators: In vitro-in vivo extrapolation (IVIVE) and in silico-in vitro based risk assessments

被引:0
|
作者
Fabian, E. [1 ]
Haase, C. [1 ]
Ramirez, T. [1 ]
Gomes, C. [1 ]
Birk, B. [1 ]
van Ravenzwaay, B. [1 ]
Landsiedel, R. [1 ]
机构
[1] BASF SE, Expt Toxicol & Ecol, Ludwigshafen, Germany
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
P265
引用
收藏
页码:S79 / S79
页数:1
相关论文
共 50 条
  • [42] In silico-in vitro-in vivo studies of experimentally designed carvedilol loaded silk fibroin-casein nanoparticles using physiological based pharmacokinetic model
    Kumar, Sandeep
    Singh, Sandeep Kumar
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 96 : 403 - 420
  • [43] A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation
    Smith, Andrew K.
    Xu, Yanli
    Ropella, Glen E. P.
    Hunt, C. Anthony
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2018, 365 (01): : 127 - 138
  • [44] A Simple Physiologically Based Toxicokinetic Model for Multi-Route In Vitro-In Vivo Extrapolation
    Wambaugh, John F.
    Schacht, Celia M.
    Ring, Caroline L.
    ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2025, 12 (03): : 261 - 268
  • [45] Application of in vitro-in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) modelling to investigate the impact of the CYP2C8 polymorphism on rosiglitazone exposure
    Yeo, Karen Rowland
    Kenny, Jane R.
    Rostami-Hodjegan, Amin
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 69 (06) : 1311 - 1320
  • [46] Drug Design and Success of Prospective Mouse In Vitro-In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CLp) from Hepatocyte Intrinsic Clearance (CLint)
    Manevski, Nenad
    Umehara, Kenichi
    Parrott, Neil
    MOLECULAR PHARMACEUTICS, 2023, 20 (07) : 3438 - 3459
  • [47] The absorption of polycyclic aromatic hydrocarbons into the skin to elicit cutaneous inflammation: The establishment of structure-permeation and in silico-in vitro-in vivo relationships
    Alalaiwe, Ahmed
    Lin, Yin-Ku
    Lin, Chih-Hung
    Wang, Pei-Wen
    Lin, Jie-Yu
    Fang, Jia-You
    CHEMOSPHERE, 2020, 255
  • [48] Mechanism-based pharmacokinetic/pharmacodynamic Modeling of the electroencephalogram effects of GABAA receptor modulators:: In vitro-in vivo correlations
    Visser, SAG
    Wolters, FLC
    Gubbens-Stibbe, JM
    Tukker, E
    Van der Graaf, PH
    Peletier, LA
    Danhof, M
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 304 (01): : 88 - 101
  • [49] Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro-in vivo extrapolation
    Algharably, Engi Abdelhady
    Di Consiglio, Emma
    Testai, Emanuela
    Pistollato, Francesca
    Bal-Price, Anna
    Najjar, Abdulkarim
    Kreutz, Reinhold
    Gundert-Remy, Ursula
    FRONTIERS IN PHARMACOLOGY, 2023, 14
  • [50] Bioconcentration Assessment in Fish Based on In Vitro Intrinsic Clearance: Predictivity of an Empirical Model Compared to In Vitro-In Vivo Extrapolation Models
    Laue, Heike
    Hostettler, Lu
    Jenner, Karen J.
    Sanders, Gordon
    Natsch, Andreas
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2023, 57 (36) : 13325 - 13335