A novel amorphous preparation improved curcumin bioavailability in healthy volunteers: A single-dose, double-blind, two-way crossover study

被引：18

作者：

Sunagawa, Yoichi ^{[1
,2
,3
]}

Miyazaki, Yusuke ^{[1
,2
,3
]}

Funamoto, Masafumi ^{[1
,3
]}

Shimizu, Kana ^{[1
,3
]}

Shimizu, Satoshi ^{[1
,3
]}

Nurmila, Sari ^{[1
]}

Katanasaka, Yasufumi ^{[1
,2
,3
]}

Ito, Masashi ^{[4
]}

Ogawa, Tatsuya ^{[4
]}

Ozawa-Umeta, Hitomi ^{[4
]}

Hasegawa, Koji ^{[1
,3
]}

Morimoto, Tatsuya ^{[1
,2
,3
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, Div Mol Med, Shizuoka 4228526, Japan

[2] Shizuoka Prefectural Gen Hosp, Shizuoka 4228527, Japan

[3] Natl Hosp Org, Clin Res Inst, Kyoto Med Ctr, Div Translat Res, Kyoto 6128555, Japan

[4] Therabiopharma Inc, Kawasaki, Kanagawa 2130012, Japan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2021年 / 81卷

基金：

日本科学技术振兴机构;

关键词：

Curcumin; Bioavailability; Amorphous; Theracurmin® curcuRougeTM; ORAL BIOAVAILABILITY; LIPOSOMAL CURCUMIN; HEART-FAILURE; ABSORPTION; PARTICLE; HUMANS;

D O I：

10.1016/j.jff.2021.104443

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Curcumin derived from Curcuma longa has beneficial pharmacological effects. However, its bioavailability is very low. To improve its bioavailability, we developed a novel amorphous formulation of curcumin, called curcuRougeTM. We investigated the bioavailability of curcuRougeTM and compared its efficiency with that of Theracurmin (R). Male Sprague-Dawley rats were orally administered curcuRougeTM or Theracurmin (R) (10 mg/kg of curcumin). Based on the area under the plasma concentration-time curve, the bioavailability of curcuRougeTM was 3.7-fold higher than that of Theracurmin (R) in rats. We performed a single-dose, double-blind, two-way crossover study to compare the bioavailability of curcuRougeTM and Theracurmin (R) (90 mg of curcumin) in 12 volunteers (8 males, 4 females). The bioavailability of curcuRougeTM was 3.4-fold higher than that of Theracurmin (R). curcuRougeTM achieved Cmax in a shorter time than Theracurmin (R) in both experiments. These findings indicate that curcuRougeTM, an amorphous formulation of curcumin, shows superior bioavailability to that of Theracurmin (R).

引用

页数：8

共 32 条

[1] PHARMACOLOGY OF CURCUMA-LONGA [J].