Survival advantage of chemoradiotherapy in anaplastic thyroid carcinoma: Propensity score matched analysis with multiple subgroups

被引：10
|
作者：
Tian, Sibo [1 ]
Switchenko, Jeffrey M. [2 ]
Fei, Teng [2 ]
Press, Robert H. [1 ]
Abugideiri, Mustafa [1 ]
Saba, Nabil F. [3 ]
Owonikoko, Taofeek K. [3 ]
Chen, Amy Y. [4 ]
Beitler, Jonathan J. [1 ,3 ,4 ]
Curran, Walter J. [1 ]
Gillespie, Theresa W. [5 ]
Higgins, Kristin A. [1 ]
机构：
[1] Emory Univ, Winship Canc Inst, Dept Radiat Oncol, 1365 Clifton Rd, Atlanta, GA 30322 USA
[2] Emory Univ, Rollins Sch Publ Heath, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA
[3] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
[4] Emory Univ, Dept Otolaryngol Head & Neck Surg, Atlanta, GA 30322 USA
[5] Emory Univ, Winship Canc Inst, Dept Surg, Atlanta, GA 30322 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2020年 / 42卷 / 04期
基金：
美国国家卫生研究院;
关键词：
anaplastic thyroid carcinoma; chemoradiation; chemotherapy; national cancer data base; radiation therapy; TREATMENT OUTCOMES; CANCER; RADIATION; SURGERY; CHEMOTHERAPY; RADIOTHERAPY; COMBINATION; PACLITAXEL; PATTERNS; CARE;
D O I：
10.1002/hed.26042
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background We compared overall survival (OS) between radiation therapy (RT) and chemoradiotherapy (CRT) in patients with anaplastic thyroid carcinoma (ATC) using a large database. Methods The National Cancer Data Base was queried for ATC patients diagnosed between 2004 and 2013 who received RT or CRT. Groups were balanced by propensity score matching (PSM) on nine relevant variables. OS was also examined in five paired subgroups given known patient heterogeneity. Results Of 858 total patients, 575 received CRT and 283 received RT. CRT was associated with decreased risk of death (hazard ratio [HR] 0.66, P < .001), 1-year OS 25.5% vs 14.3%. A survival advantage to CRT was seen using PSM cohorts (HR 0.75, P = .006). Those receiving definitive surgery saw the greatest benefit to CRT over RT (HR 0.65, P = .009), 1-year OS 39.6% vs 20.4%. Conclusions CRT is associated with decreased risk of death in ATC; the magnitude of CRT vs RT benefit varied by subgroup.
引用
收藏
页码：678 / 687
页数：10
相关论文
共 50 条
  • [41] Factors Associated with Survival in Anaplastic Thyroid Carcinoma: A Multicenter Study from the ENDOCAN-TUTHYREF Network
    Jannin, Arnaud
    Giudici, Fabiola
    de la Fouchardiere, Christelle
    Al Ghuzlan, Abir
    Wassermann, Johanna
    Chougnet, Cecile N.
    Drui, Delphine
    Godbert, Yann
    Ilouz, Frederic
    Bardet, Stephane
    Zanetta, Sylvie
    Roudaut, Nathalie
    Lignier, Marie Batisse
    Groussin, Lionel
    Klein, Marc
    Zerdoud, Slimane
    Lamartina, Livia
    Baudin, Eric
    Decaussin-Petrucci, Myriam
    Leteurtre, Emmanuelle
    Chazot, Francoise Borson
    Do Cao, Christine
    Borget, Isabelle
    Hadoux, Julien
    THYROID, 2023, 33 (10) : 1190 - 1200
  • [42] A Propensity-matched Analysis Comparing Survival After Esophagectomy Followed by Adjuvant Chemoradiation to Surgery Alone for Esophageal Squamous Cell Carcinoma
    Hwang, Jwu-Yun
    Chen, Hui-Shan
    Hsu, Po-Kuei
    Chao, Yin-Kai
    Wang, Bing-Yen
    Huang, Chien-Sheng
    Liu, Chia-Chuan
    Wu, Shiao-Chi
    ANNALS OF SURGERY, 2016, 264 (01) : 100 - 106
  • [43] Does higher radiation dose lead to better outcome for non-operated localized esophageal squamous cell carcinoma patients who received concurrent chemoradiotherapy? A population based propensity-score matched analysis
    Chen, Chih-Yi
    Li, Chia-Chin
    Chien, Chun-Ru
    RADIOTHERAPY AND ONCOLOGY, 2016, 120 (01) : 136 - 139
  • [44] Role of surgery to the primary tumor in metastatic anaplastic thyroid carcinoma: pooled analysis and SEER-based study
    Oliinyk, Dmytro
    Augustin, Teresa
    Rauch, Josefine
    Koehler, Viktoria Florentine
    Belka, Claus
    Spitzweg, Christine
    Kaesmann, Lukas
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (07) : 3527 - 3547
  • [45] Survival outcomes of hepatocellular carcinoma resection with postoperative complications - a propensity-score-matched analysis
    Chok, Kenneth S. H.
    Chan, Millies M. Y.
    Dai, Wing Chiu
    Chan, Albert C. Y.
    Cheung, Tan To
    Wong, Tiffany C. L.
    She, Wong Hoi
    Lo, Chung Mau
    MEDICINE, 2017, 96 (12)
  • [46] IMRT improves local control in patients with nasopharyngeal carcinoma compared with conventional radiotherapy: propensity score-matched analysis
    Ma, Zichang
    Umezawa, Rei
    Yamamoto, Takaya
    Ishikawa, Yojiro
    Takahashi, Noriyoshi
    Takeda, Kazuya
    Suzuki, Yu
    Tang, Liuwei
    Ito, Kengo
    Kadoya, Noriyuki
    Jingu, Keiichi
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 51 (09) : 1444 - 1451
  • [47] Identification of Patients for Adjuvant Therapy After Resection of Carcinoma of the Extrahepatic Bile Ducts: A Propensity Score-Matched Analysis
    Ecker, Brett L.
    Vining, Charles C.
    Roses, Robert E.
    Maggino, Laura
    Lee, Major K.
    Drebin, Jeffrey A.
    Fraker, Douglas L.
    Vollmer, Charles M., Jr.
    Datta, Jashodeep
    ANNALS OF SURGICAL ONCOLOGY, 2017, 24 (13) : 3926 - 3933
  • [48] The Impact of Radiation Dose on Preoperative Neoadjuvant Chemoradiotherapy Effects for Patients with Locally Advanced Squamous Cell Esophageal Carcinoma: A Propensity Score-Matched Retrospective Study
    Mu, Yanru
    Wang, Hui
    He, Tao
    Xu, Li
    JOURNAL OF IMMUNOLOGY RESEARCH, 2022, 2022
  • [49] Meta-analysis of survival benefit with postoperative chemoradiotherapy in patients of lymph node positive esophageal carcinoma
    Luo, H.
    Cui, Y. Y.
    Zhang, J. G.
    Sun, Y. N.
    Zheng, X. L.
    Yang, C. L.
    Ye, K.
    Ge, H.
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2018, 20 (07) : 889 - 898
  • [50] Chemoradiotherapy Is Superior to Radiotherapy Alone in Esophageal Cancer Patients Older Than 65 Years: A Propensity Score-Matched Analysis of the SEER Database
    Xia, Xiaojie
    Gao, Qing
    Ge, Xiaolin
    Liu, Zeyuan
    Di, Xiaoke
    Sun, Xinchen
    Yang, Yan
    FRONTIERS IN ONCOLOGY, 2021, 11
12345