M-cell surface β1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer's patch M cells

被引：280

作者：

Clark, MA ^{[1
]}

Hirst, BH ^{[1
]}

Jepson, MA ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Sch Med, Dept Physiol Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.66.3.1237-1243.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Quantitative analysis of Yersinia pseudotuberculosis infection of murine gut loops revealed that significantly more wild-type bacteria associated with Peyer's patch M cells than with dome enterocytes or goblet cells. An invasin-deficient mutant was significantly attenuated for M-cell invasion, while beta 1 integrin expression was demonstrated in the apical membranes of M cells but not enterocytes. M-cell targeting by Yersinia pseudotuberculosis in vivo may, therefore, be mediated primarily by the interaction of invasin with cell surface beta 1 integrins.

引用

页码：1237 / 1243

页数：7

共 42 条

[1] Penetration of M cells and destruction of Peyer's patches by Yersinia enterocolitica: An ultrastructural and histological study [J].