A Stiff Blow from the Stroma: Collagen Crosslinking Drives Tumor Progression

被引：106

作者：

Ng, Mei Rosa ^{[1
]}

Brugge, Joan S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CANCER CELL | 2009年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.ccr.2009.11.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Matrix stiffness is an important microenvironmental cue that regulates cell growth, motility, and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to enhanced integrin signaling and invasive behavior in tumors.

引用

收藏

页码：455 / 457

页数：3

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