Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats

被引：71

作者：

Quevedo, J

Vianna, MRM

Martins, MR

Barichello, T

Medina, JH

Roesler, R

Izquierdo, I

机构：

[1] Univ Extremo Sul Catarinense, Lab Neurotoxicol, BR-88806000 Criciuma, Brazil

[2] Univ Fed Rio Grande Sul, Dept Bioquim, Ctr Mem, Inst Ciencias Basicas Saude, BR-90035003 Porto Alegre, RS, Brazil

[3] Univ Buenos Aires, Fac Med, Lab Neurorreceptores, Inst Biol Celular & Neurociencia Eduardo Robertis, Buenos Aires, DF, Argentina

[4] Univ Fed Rio Grande Sul, Inst Ciencias Basicas Saude, Dept Farmacol, Lab Neurofarmacol Preclin, BR-90046900 Porto Alegre, RS, Brazil

来源：

BEHAVIOURAL BRAIN RESEARCH | 2004年 / 154卷 / 02期

关键词：

short-term memory; long-term memory; hippocampus; protein synthesis; cAMP-dependent protein kinase (PKA); mitogen-activated protein kinase (MAPK);

D O I：

10.1016/j.bbr.2004.03.001

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We studied the involvement of hippocampal protein synthesis-, PKA-, and MAP kinase-dependent processes in short- (STM) and Iona-term memory (LTM) for inhibitory avoidance task. Fifteen minutes before or immediately after training rats received intrahippocampal infusions of vehicle, the protein synthesis inhibitor anisomycin, the PKA inhibitor Rp-cAMPs or the MAPKK inhibitor PD098059. The results show that STM recruits PKA and MAPK, whereas, LTM depends on PKA activity and protein synthesis during the early post-training period. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：339 / 343

页数：5

共 30 条

[1] Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory [J].