Antibacterial and antioxidant potential of biosynthesized copper nanoparticles mediated through Cissus arnotiana plant extract

被引:276
作者
Rajeshkumar, S. [1 ]
Menon, Soumya [2 ]
Kumar, Venkat S. [2 ]
Tambuwala, Murtaza M. [3 ]
Bakshi, Hamid A. [3 ]
Mehta, Meenu [4 ]
Satija, Saurabh [4 ]
Gupta, Gaurav [5 ]
Chellappan, Dinesh Kumar [6 ]
Thangavelu, Lakshmi [1 ]
Dua, Kamal [7 ,8 ]
机构
[1] SIMATS, Saveetha Dent Coll & Hosp, Dept Pharmacol, Chennai 600077, Tamil Nadu, India
[2] VIT, Sch Biosci & Technol, Vellore 632014, Tamil Nadu, India
[3] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland
[4] Lovely Profess Univ, Sch Pharmaceut Sci, Jalandhar Delhi GT Rd,NH-1, Phagwara 144411, Punjab, India
[5] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur, Rajasthan, India
[6] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia
[7] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia
[8] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW 2308, Australia
关键词
Copper nanoparticles; DPPH assay; Antibacterial activity; Morphology evaluation; Peptidoglycan layer; Electrostatic interactions; Therapeutic applications; GREEN SYNTHESIS; OXIDE NANOPARTICLES; SILVER NANOPARTICLES; ANTIMICROBIAL ACTIVITY; EFFICIENT; NANOCOMPOSITES; CATALYST;
D O I
10.1016/j.jphotobiol.2019.111531
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Environment friendly methods for the synthesis of copper nanoparticles have become a valuable trend in the current scenario. The utilization of phytochemicals from plant extracts has become a unique technology for the synthesis of nanoparticles, as they possess dual nature of reducing and capping agents to the nanoparticles. In the present investigation we have synthesized copper nanoparticles (CuNPs) using a rare medicinal plant Cissus arnotiana and evaluated their antibacterial activity against gram negative and gram positive bacteria. The morphology and characterization of the synthesized CuNPs were studied and done using UV-Visible spectroscopy at a wavelength range of 350-380 nm. XRD studies were performed for analyzing the crystalline nature; SEM and TEM for evaluating the spherical shape within the size range of 60-90 nm and AFM was performed to check the surface roughness. The biosynthesized CuNPs showed better antibacterial activity against the gram negative bacteria, E. colt with an inhibition zone of 22.20 +/- 0.16 mm at 75 mu g/ml. The antioxidant property observed was comparatively equal with the standard antioxidant agent ascorbic acid at a maximum concentration of 40 mu g/ml. This is the first study reported on C. arnotiana mediated biosynthesis of copper nano particles, where we believe that the findings can pave way for a new direction in the field of nanotechnology and nanomedicine where there is a significant potential for antibacterial and antioxidant activities. We predict that, these could lead to an exponential increase in the field of biomedical applications, with the utilization of green synthesized CuNPs, due to its remarkable properties. The highest antibacterial property was observed with gram negative strains mainly, E. coli, due to its thin peptidoglycan layer and electrostatic interactions between the bacterial cell wall and CuNPs surfaces. Hence, CuNPs can be potent therapeutic agents in several biomedical applications, which are yet to be explored in the near future.
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页数:6
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