Maternal Periodontal Disease and Risk of Preeclampsia: A Meta-analysis

被引:19
作者
Huang, Xi [1 ]
Wang, Juan [2 ]
Liu, Jian [1 ]
Hua, Li [1 ]
Zhang, Dan [3 ]
Hu, Ting [2 ]
Ge, Zi-li [1 ]
机构
[1] Soochow Univ, Affiliated Hosp 1, Dept Stomatol, Suzhou 215006, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Gynaecol & Obstet, Suzhou 215006, Peoples R China
[3] Soochow Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Suzhou 215006, Peoples R China
关键词
periodontal disease; preeclampsia; risk factor; pregnancy; meta-analysis; ORAL-HEALTH; PREGNANCY; ASSOCIATION;
D O I
10.1007/s11596-014-1343-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Research on the association between maternal periodontal disease and the risk of preeclampsia has generated inconsistent results. This meta-analysis was conducted to evaluate the association between maternal periodontal disease and the risk of preeclampsia. A literature search of PubMed and Embase was performed to identify relevant papers published before March 2013. Only observational studies that assessed maternal periodontal disease and the risk of preeclampsia were selected. Patients' periodontal status was examined at different time points during pregnancy or after delivery (at 14-32 weeks of gestation, within 48 h prior to or within 5 days after delivery). Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated for cases and controls. Cases were defined as women with concurrent hypertension and proteinuria after 20 weeks of gestation. Eleven studies involving 1118 women with preeclampsia and 2798 women without preeclampsia were identified and analyzed. Women with periodontal disease before 32 weeks of gestation had a 3.69-fold higher risk of developing preeclampsia than their counterparts without periodontal disease (OR=3.69; 95% CI=2.58-5.27). Periodontal disease within 48 h prior to delivery was associated with a 2.68-fold higher risk of preeclampsia (OR=2.68; 95% CI=1.39-5.18). Pregnant women with periodontal disease within 5 days after delivery had a 2.22-fold higher risk of preeclampsia than women without periodontal disease (OR=2.22; 95% CI=1.16-4.27). In conclusion, this meta-analysis suggests that maternal periodontal disease is an independent predictor of preeclampsia.
引用
收藏
页码:729 / 735
页数:7
相关论文
共 32 条
[1]   OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS [J].
BEGG, CB ;
MAZUMDAR, M .
BIOMETRICS, 1994, 50 (04) :1088-1101
[2]   Maternal, periodontal disease is associated with an increased risk for preeclampsia [J].
Boggess, KA ;
Lieff, S ;
Murtha, AP ;
Moss, K ;
Beck, J ;
Offenbacher, S .
OBSTETRICS AND GYNECOLOGY, 2003, 101 (02) :227-231
[3]   Maternal oral health in pregnancy [J].
Boggess, Kim A. .
OBSTETRICS AND GYNECOLOGY, 2008, 111 (04) :976-986
[4]   Periodontal disease as a risk factor for pre-eclampsia: A case control study [J].
Canakci, V ;
Canakci, CF ;
Canakci, H ;
Canakci, E ;
Cicek, Y ;
Ingec, M ;
Ozgoz, M ;
Demir, T ;
Dilsiz, A ;
Yagiz, H .
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2004, 44 (06) :568-573
[5]  
Canakci V, 2007, J CLIN PERIODONTOL, V34, P639, DOI 10.1111/j.1600-051X.2007.01105.x
[6]   Periodontal disease:: Is it a risk factor for premature labor, low birth weight or preeclampsia? [J].
Castaldi, JL ;
Bertin, MS ;
Giménez, F ;
Lede, R .
REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH, 2006, 19 (04) :253-258
[7]   Adhesion molecules changes at 20 gestation weeks in pregnancies complicated by preeclampsia [J].
Chavarria, Maria E. ;
Lara-Gonzalez, Lina ;
Garcia-Paleta, Yolanda ;
Vital-Reyes, Victor S. ;
Reyes, Alejandro .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2008, 137 (02) :157-164
[8]   Maternal infection and risk of preeclampsia: Systematic review and metaanalysis [J].
Conde-Agudelo, Agustin ;
Villar, Jose ;
Lindheimer, Marshall .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2008, 198 (01) :7-22
[9]   Periodontitis is associated with preeclampsia in pregnant women [J].
Contreras, A. ;
Herrera, J. A. ;
Soto, J. E. ;
Arce, R. M. ;
Jaramillo, A. ;
Botero, J. E. .
JOURNAL OF PERIODONTOLOGY, 2006, 77 (02) :182-188
[10]   Periodontitis as a Risk Factor for Preeclampsia [J].
da Silva, Genivaldo Moura ;
Coutinho, Sonia B. ;
Piscoya, Maria Dilma B. V. ;
Ximenes, Ricardo A. A. ;
Jamelli, Silvia R. .
JOURNAL OF PERIODONTOLOGY, 2012, 83 (11) :1388-1396