A Novel Recombinant Fusion Protein Exhibited Inhibitory Activities on Platelet Aggregation and Thrombin

被引：0
|
作者：
Hu, Zongli [1 ]
Zhao, Zhiping [1 ]
Liang, Yan [1 ]
Li, Yong [1 ]
Chen, Guoping [1 ]
机构：
[1] Chongqing Univ, Minist Educ, Bioengn Coll, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Thrombosis; Hirudin; 12-residue; Thrombin; NAP5; Platelet aggregation; Recombinant fusion protein; DEEP-VEIN THROMBOSIS; ANTICOAGULANT PEPTIDE; PULMONARY-EMBOLISM; HIRUDIN; THROMBOEMBOLISM; COAGULATION; HEPARIN;
D O I：
10.2174/157018010790596605
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We designed a novel recombinant fusion protein r-NAP5-hirudin 12-residue- RGD with bi-functional inhibitory activities against platelet aggregation and thrombin. Our strategy may supply a potential multi-functional drug for the prevention and management of thrombosis.
引用
收藏
页码：182 / 187
页数：6
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