Rationale for the Role of Heparin and Related GAG Antithrombotics in COVID-19 Infection

被引：19
作者：
Magnani, Harry N. [1 ]
机构：
[1] Aspen Pharma, Schoutstr 54, NL-5345 MT Oss, Netherlands
来源：
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2021年 / 27卷
关键词：
COVID-19; pathophysiology; GAG-antithrombotics; danaparoid sodium; sulodexide; INDUCED THROMBOCYTOPENIA; DERMATAN SULFATE; PLATELET-FACTOR-4; COAGULATION; HEPARANASE; THROMBOMODULIN; ACTIVATION; SULODEXIDE; ANTIBODIES; SUBSTRATE;
D O I：
10.1177/1076029620977702
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The SARS-CoV-2 pandemic has focused attention on prevention, restriction and treatment methods that are acceptable worldwide. This means that they should be simple and inexpensive. This review examines the possible role of glycosaminoglycan (GAG) antithrombotics in the treatment of COVID-19. The pathophysiology of this disease reveals a complex interplay between the hemostatic and immune systems that can be readily disrupted by SARS-CoV-2. Some of the GAG antithrombotics also possess immune-modulatory actions and since they are relatively inexpensive they could play an important role in the management of COVID-19 and its complications.
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页数：26
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