Analysis of microRNAs induced by Venezuelan equine encephalitis virus infection in mouse brain

被引：17

作者：

Bhomia, Manish ^{[3
]}

Balakathiresan, Nagaraja ^{[2
]}

Sharma, Anuj

Gupta, Paridhi ^{[3
]}

Biswas, Roopa ^{[2
]}

Maheshwari, Radha ^{[1
]}

机构：

[1] Uniformed Serv Univ Hlth Sci, Dept Pathol, Ctr Combat Casualty & Life Sustainment Res, Bethesda, MD 20814 USA

[2] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA

[3] Birla Inst Technol & Sci, Biol Sci Grp, Pilani 333031, Rajasthan, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 395卷 / 01期

关键词：

MicroRNA profiling; Venezuelan equine encephalitis virus; Alphavirus infection; Real-time PCR; mRNA expression; HEPATITIS-C VIRUS; CELLULAR MICRORNAS; EXPRESSION; REPLICATION; NEURODEGENERATION; PATHOGENESIS; SYSTEM; GENES; CELLS; MICE;

D O I：

10.1016/j.bbrc.2010.03.091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNA) are small RNA (similar to 22nts) molecules that are expressed endogenously in cells and play an important role in regulating gene expression. Recent studies have shown that cellular miRNA plays a very important role in the pathogenesis of viral infection. Venezuelan equine encephalitis virus (VEEV) is an RNA virus and is a member of the genus Alphavirus in the family Togaviridae. VEEV is infectious in aerosol form and is a potential biothreat agent. In this study, we report for the first time that VEEV infection in mice brain causes modulation of miRNA expression. Pathway analyses showed that majority of these miRNAs are involved in the neuronal development and function. Target gene prediction of the modulated miRNAs correlates with our recently reported mRNA expression in VEEV infected mice brain. Published by Elsevier Inc.

引用

页码：11 / 16

页数：6

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