Hydrocarbon oxidation vs C-C bond-forming approaches for efficient syntheses of oxygenated molecules

被引：98
作者：
Fraunhoffer, KJ [1 ]
Bachovchin, DA [1 ]
White, MC [1 ]
机构：
[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 02期
关键词：
D O I：
10.1021/ol047800p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A hydrocarbon oxidation approach has been applied to the construction of several linear (E)-allylic alcohols that have served as intermediates in the synthesis of natural products and natural product-like molecules. In the original syntheses.. these intermediates were constructed using a standard Wittig-type olefination approach. We report here that routes to these same intermediates designed around a hydrocarbon oxidation approach are more efficient both in the total number of functional group manipulations (FGMs) and overall steps, as well as in the overall yield.
引用
收藏
页码：223 / 226
页数：4
相关论文
共 26 条
123