Hydrocarbon oxidation vs C-C bond-forming approaches for efficient syntheses of oxygenated molecules

被引：98

作者：

Fraunhoffer, KJ ^{[1
]}

Bachovchin, DA ^{[1
]}

White, MC ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 02期

关键词：

D O I：

10.1021/ol047800p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A hydrocarbon oxidation approach has been applied to the construction of several linear (E)-allylic alcohols that have served as intermediates in the synthesis of natural products and natural product-like molecules. In the original syntheses.. these intermediates were constructed using a standard Wittig-type olefination approach. We report here that routes to these same intermediates designed around a hydrocarbon oxidation approach are more efficient both in the total number of functional group manipulations (FGMs) and overall steps, as well as in the overall yield.

引用

页码：223 / 226

页数：4

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