In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls

被引：50
作者：
Hinze-Selch, D
Wetter, TC
Zhang, Y
Lu, HC
Albert, ED
Mullington, J
Wekerle, H
Holsboer, F
Pollmächer, T
机构：
[1] Max Planck Inst Psychiat, Inst Clin, D-80804 Munich, Germany
[2] Max Planck Inst Psychiat, Theoret Inst, D-8033 Martinsried, Germany
[3] Univ Munich, Immunogenet Lab, Munich, Germany
[4] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
来源：
NEUROLOGY | 1998年 / 50卷 / 04期
关键词：
D O I：
10.1212/WNL.50.4.1149
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We investigated cytokine levels (interleukin [IL]-1 beta, IL-1ra, IL-2, IL-6, tumor necrosis factor [TNF]-alpha, TNF-beta) in plasma and secreted by mitogen-stimulated blood monocytes and lymphocytes; T-cell subsets; and natural killer cell activity in patients with narcolepsy and in human leukocyte antigen (HLA)-DR2 matched controls. The only significant finding was higher IL-6 secretion by monocytes of patients than by those of the HLA-DR2-positive controls. In conclusion, we found no major abnormalities of T-cell function in patients with narcolepsy, but slight alterations of monocyte function deserving further investigation.
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页码：1149 / 1152
页数：4
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