Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation

被引：134

作者：

Li, Xu-Hui ^{[1
,2
,3
]}

Matsuura, Takanori ^{[2
,4
]}

Xue, Man ^{[1
]}

Chen, Qi-Yu ^{[1
,3
]}

Liu, Ren-Hao ^{[1
]}

Lu, Jing-Shan ^{[1
,3
]}

Shi, Wantong ^{[1
]}

Fan, Kexin ^{[1
]}

Zhou, Zhaoxiang ^{[1
]}

Miao, Zhuang ^{[2
]}

Yang, Jiale ^{[5
]}

Wei, Sara ^{[5
]}

Wei, Feng ^{[5
]}

Chen, Tao ^{[1
,6
,7
]}

Zhuo, Min ^{[1
,2
,3
]}

机构：

[1] Xi An Jiao Tong Univ, Ctr Neuron & Dis, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China

[2] Univ Toronto, Fac Med, Dept Physiol, Med Sci Bldg,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada

[3] Qingdao Int Academician Pk, Inst Brain Res, Qingdao, Shandong, Peoples R China

[4] Univ Occupat & Environm Hlth, Sch Med, Dept Orthopaed, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

[5] Univ Maryland, Dept Neural & Pain Sci, Sch Dent, Baltimore, MD 20201 USA

[6] Fourth Mil Med Univ, Dept Anat Histol Embryol, Xian 710032, Peoples R China

[7] Fourth Mil Med Univ, KK Leung Brain Res Ctr, Xian 710032, Peoples R China

来源：

CELL REPORTS | 2021年 / 36卷 / 03期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

INDUCED ANALGESIA; FEAR; RECEPTOR; NEURONS; MECHANISMS; CIRCUITS; BEHAVIOR; IMPROVES; MEMORY; BRAIN;

D O I：

10.1016/j.celrep.2021.109411

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oxytocin is a well-known neurohypophysial hormone that plays an important role in behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic LTP (pre-LTP) and postsynaptic LTP (post-LTP), have been characterized in the anterior cingulate cortex (ACC). Both pre-LTP and post-LTP contribute to chronic-pain-related anxiety and behavioral sensitization. The roles of oxytocin in the ACC have not been studied. Here, we find that microinjections of oxytocin into the ACC attenuate nociceptive responses and anxiety-like behavioral responses in animals with neuropathic pain. Application of oxytocin selectively blocks the maintenance of pre-LTP but not post-LTP. In addition, oxytocin enhances inhibitory transmission and excites ACC interneurons. Similar results are obtained by using selective optical stimulation of oxytocin-containing projecting terminals in the ACC in animals with neuropathic pain. Our results demonstrate that oxytocin acts on central synapses and reduces chronic-pain-induced anxiety by reducing pre-LTP.

引用

页数：21