Reductive CO2 Fixation via Tandem C-C and C-N Bond Formation: Synthesis of Spiro-indolepyrrolidines

被引：68
|
作者：
Zhu, Dao-Yong [1 ]
Fang, Lei [1 ]
Han, Hui [1 ]
Wang, Yazhou [1 ]
Xia, Ji-Bao [1 ]
机构：
[1] Chinese Acad Sci, LICP, Suzhou Res Inst LICP, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 16期
关键词：
CARBON-DIOXIDE; HETEROCYCLIC CARBENE; CATALYTIC METHYLATION; BUILDING-BLOCK; METAL-FREE; H BONDS; ENANTIOSELECTIVE CONSTRUCTION; CARBOXYLIC-ACIDS; UNIFIED STRATEGY; AMINES;
D O I：
10.1021/acs.orglett.7b01906
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe herein a tendem C-C and C-N bond forming reaction in the reductive functionalization of CO2, an abundant and cheap Cl chemical-feedstock. This catalytic Metal-free CO2, fixation afforded spiro-indoleyrrolidines by dearomatization of tryptamine derivatives with broad scope and good functional group tolerance under mild conditions.
引用
收藏
页码：4259 / 4262
页数：4
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