Unexpected steps in plasma-cell differentiation

被引：13

作者：

Klein, Ulf

Dalla-Favera, Riccardo

机构：

[1] Columbia Univ, Inst Canc Genet, New York, NY 10032 USA

[2] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

来源：

IMMUNITY | 2007年 / 26卷 / 05期

关键词：

BLIMP-1; PROTEIN; PAX5;

D O I：

10.1016/j.immuni.2007.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transcriptional repressor Blimp-1 is considered the master regulator of plasma-cell differentiation. In this issue of Immunity, Kallies et al. (2007) identify a Blimp-1-independent stage of differentiation, followed by Blimp-1-dependent terminal differentiation.

引用

收藏

页码：543 / 544

页数：2

相关论文

共 10 条

[1] Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells [J].

Delogu, A ;

Schebesta, A ;

Sun, Q ;

Aschenbrenner, K ;

Perlot, T ;

Busslinger, M .

IMMUNITY, 2006, 24 (03) :269-281

[2] Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1 [J].

Kallies, Axel ;

Hasbold, Jhagvaral ;

Fairfax, Kirsten ;

Pridans, Clare ;

Emslie, Dianne ;

McKenzie, Brent S. ;

Lew, Andrew M. ;

Corcoran, Lynn M. ;

Hodgkin, Philip D. ;

Tarlinton, David M. ;

Nutt, Stephen L. .

IMMUNITY, 2007, 26 (05) :555-566

[3] Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination [J].

Klein, Ulf ;

Casola, Stefano ;

Cattoretti, Giorgio ;

Shen, Qiong ;

Lia, Marie ;

Mo, Tongwei ;

Ludwig, Thomas ;

Rajewsky, Klaus ;

Dalla-Favera, Riccardo .

NATURE IMMUNOLOGY, 2006, 7 (07) :773-782

[4] Loss of Pax5 promotes plasma cell differentiation [J].

Nera, KP ;

Kohonen, P ;

Narvi, E ;

Peippo, A ;

Mustonen, L ;

Terho, P ;

Koskela, K ;

Buerstedde, JM ;

Lassila, O .

IMMUNITY, 2006, 24 (03) :283-293

[5] Plasma cell differentiation requires the transcription factor XBP-1 [J].

Reimold, AM ;

Iwakoshi, NN ;

Manis, J ;

Vallabhajosyula, P ;

Szomolanyi-Tsuda, E ;

Gravallese, EM ;

Friend, D ;

Grusby, MJ ;

Alt, F ;

Glimcher, LH .

NATURE, 2001, 412 (6844) :300-307

[6] Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation [J].

Sciammas, Roger ;

Shaffer, A. L. ;

Schatz, Jonathan H. ;

Zhao, Hong ;

Staudt, Louis M. ;

Singh, Harinder .

IMMUNITY, 2006, 25 (02) :225-236

[7] XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation [J].

Shaffer, AL ;

Shapiro-Shelef, M ;

Iwakoshi, NN ;

Lee, AH ;

Qian, SB ;

Zhao, H ;

Yu, X ;

Yang, LM ;

Tan, BK ;

Rosenwald, A ;

Hurt, EM ;

Petroulakis, E ;

Sonenberg, N ;

Yewdell, JW ;

Calame, K ;

Glimcher, LH ;

Staudt, LM .

IMMUNITY, 2004, 21 (01) :81-93

[8] Regulation of plasma-cell development [J].

Shapiro-Shelef, M ;

Calame, K .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (03) :230-242

[9] BLIMP-1, A NOVEL ZINC FINGER-CONTAINING PROTEIN THAT CAN DRIVE THE MATURATION OF B-LYMPHOCYTES INTO IMMUNOGLOBULIN-SECRETING CELLS [J].

TURNER, CA ;

MACK, DH ;

DAVIS, MM .

CELL, 1994, 77 (02) :297-306

[10] The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation [J].

Ye, BH ;

Cattoretti, G ;

Shen, QO ;

Zhang, JD ;

Hawe, N ;

deWaard, R ;

Leung, C ;

NouriShirazi, M ;

Orazi, A ;

Chaganti, RSK ;

Rothman, P ;

Stall, AM ;

Pandolfi, PP ;

DallaFavera, R .

NATURE GENETICS, 1997, 16 (02) :161-170