On the modeling of mechanotransduction in flow-mediated dilation

被引:2
作者
Sidnawi, Bchara [1 ,2 ]
Chen, Zhen [3 ]
Sehgal, Chandra [3 ]
Santhanam, Sridhar [1 ]
Wu, Qianhong [1 ,2 ]
机构
[1] Villanova Univ, Dept Mech Engn, 800 Lancaster Ave, Villanova, PA 19085 USA
[2] Villanova Univ, Cellular Biomech & Sport Sci Lab, Villanova, PA 19085 USA
[3] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
基金
美国国家科学基金会;
关键词
Flow mediated dilation; Fluid-structure interaction; Mechanotransduction; Wall shear stress; Model; ENDOTHELIAL NOS ACTIVATION; FLUID SHEAR-STRESS; GLYCOCALYX; DILATATION; IMPAIRMENT; GLYPICAN-1; SMOKING; MEN;
D O I
10.1016/j.jmbbm.2021.104606
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In this paper, we report a physics based mathematical model to describe the mechanotransduction at the luminal surface of the brachial artery during a flow-mediated dilation (FMD) process. To account for the effect of the released vasodilators in response to the sudden blood flow resurgence, a scalar property is introduced as a signal radially diffusing through the arterial wall, locally affecting its compliance. The model was evaluated on 19 in vivo responses of brachial artery FMD (BAFMD) in 12 healthy subjects. It successfully reproduces the timedependent dilation of the brachial artery. The predicted artery's outer-to-inner radius ratio was also found to be consistent with the measurements within an acceptable margin of error. Physically meaningful dimensionless parameters quantifying the artery's physical state arose from the model, providing a description to how sensitive or responsive the artery is to the changes of wall shear stress (WSS). Future applications of this model, via incorporating inexpensive, relatively quick, and non-invasive imaging, could potentially help detect early stages of developing forms of cardiovascular diseases.
引用
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页数:12
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