Synergistic effect of combined transcranial direct current stimulation and Matrix Model on the reduction of methamphetamine craving and improvement of cognitive functioning: a randomized sham-controlled study

被引:10
作者
Feyzi, Yasha Fayaz [1 ]
Vahed, Neda [1 ]
Nikraftar, Nazanin Sadeghamal [2 ]
Arezoomandan, Reza [1 ]
机构
[1] Iran Univ Med Sci, Tehran Inst Psychiat, Sch Behav Sci & Mental Hlth, Dept Addict, Niayesh St,Shahid Mansuri Ave,POB 14565-441, Tehran, Iran
[2] Islamic Azad Univ, Dept Clin Pharm, Pharmaceut Sci Branch, Tehran, Iran
关键词
Methamphetamine; transcranial direct current stimulation (tDCS); craving; cognitive functioning; working memory; executive function; DORSOLATERAL PREFRONTAL CORTEX; DRUG-USE SCALE; INITIAL VALIDATION; TDCS; ADDICTION; QUESTIONNAIRE; INDIVIDUALS; MODULATION; USERS;
D O I
10.1080/00952990.2021.2015771
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background: Addiction is associated with decreased activity of the prefrontal networks, especially dorsolateral prefrontal cortex (DLPFC). Objective: This study examined the effectiveness of transcranial direct current stimulation (tDCS) over DLPFC in combination with Matrix Model psychotherapy in the alleviation of craving and cognitive improvement of participants with methamphetamine use disorder. Methods: In a randomized and sham-controlled trial, 60 male participants were assigned to Matrix psychotherapy only, sham tDCS plus Matrix, or active tDCS plus Matrix. Sixteen sessions of 20-min anodal (2 mA over F3 for targeting the left DLPFC) or sham tDCS along were administered in the outpatient setting. Pre- and post-intervention craving, executive functioning, and working memory were assessed using the Obsessive-Compulsive Drug Use Scale, Wisconsin Card Sorting Test, and Wechsler Memory Scale, respectively. One month following the interventions relapse was investigated by urine drug screen or interview. Results: In comparison with sham tDCS (n = 12) and Matrix psychotherapy only group (n = 13), the active tDCS group (n = 15) showed more reduction in craving (p<.05, eta(2) = .21). Auditory and visual memory (Wechsler) and true answers and false answers (WCST) significantly improved in the active tDCS group (eta(2) = .18, eta(2) = 12, eta(2) = 03, eta(2) = .02, respectively) but not in the other groups. Relapse rates did not significantly differ between groups (p = .17). A significant correlation was found between craving reduction and cognitive functioning in the active tDCS group. Conclusion: The combination of Matrix Model psychotherapy and tDCS may an effective therapy for cognitive improvement and craving in participants with methamphetamine use disorder.
引用
收藏
页码:311 / 320
页数:10
相关论文
共 49 条
[1]   Methamphetamine use and treatment in Iran: A systematic review from the most populated Persian Gulf country [J].
Alam-mehrjerdi, Zahra ;
Mokri, Azarakhsh ;
Dolan, Kate .
ASIAN JOURNAL OF PSYCHIATRY, 2015, 16 :17-25
[2]   Successful Use of Minocycline for the Treatment of Methamphetamine-Induced Psychosis and Cognitive Impairments: An Open-Label Case Series [J].
Alavi, Sasan ;
Darharaj, Mohammad ;
Bilehsavar, Shirin Haghshenas ;
Amini, Mahdi ;
Zafarghandi, Mohammad Bagher Saberi ;
Berenji, Vahid ;
Arezoomandan, Reza .
CLINICAL NEUROPHARMACOLOGY, 2021, 44 (04) :126-131
[3]   Repeated stimulation of the dorsolateral-prefrontal cortex improves executive dysfunctions and craving in drug addiction: A randomized, double-blind, parallel-group study [J].
Alizadehgoradel, Jaber ;
Nejati, Vahid ;
Movahed, Fariba Sadeghi ;
Imani, Saeed ;
Taherifard, Mina ;
Mosayebi-Samani, Mohsen ;
Vicario, Carmelo M. ;
Nitsche, Michael A. ;
Salehinejad, Mohammad Ali .
BRAIN STIMULATION, 2020, 13 (03) :582-593
[4]  
Anaraki M., 2019, IRAN REHABIL J, V17, P385, DOI [10.32598/irj.17.4.385, DOI 10.32598/IRJ.17.4.385]
[5]  
Anderson K., 2018, MODEL PROGRAM TREATI
[6]  
Ankri Y., 2017, Brain Stimul, V10, P350, DOI [10.1016/j.brs.2017.01.026, DOI 10.1016/J.BRS.2017.01.026]
[7]   The therapeutic effects of methylphenidate and matrix-methylphenidate on addiction severity, craving, relapse and mental health in the methamphetamine use disorder [J].
Aryan, Nazanin ;
Banafshe, Hamid Reza ;
Farnia, Vahid ;
Shakeri, Jalal ;
Alikhani, Mostafa ;
Rahimi, Habibollah ;
Sehat, Mojtaba ;
Mamsharifi, Peyman ;
Ghaderi, Amir ;
Omidi, Abdollah .
SUBSTANCE ABUSE TREATMENT PREVENTION AND POLICY, 2020, 15 (01)
[8]  
Barati M, 2014, J RES HEALTH SCI, V14, P221
[9]   A Meta-Analysis of the Relationship Between Abstinence and Neuropsychological Functioning in Methamphetamine Use Disorder [J].
Basterfield, Candice ;
Hester, Robert ;
Bowden, Stephen C. .
NEUROPSYCHOLOGY, 2019, 33 (05) :739-753
[10]   A Randomized Placebo-Controlled Trial of Targeted Prefrontal Cortex Modulation with Bilateral tDCS in Patients with Crack-Cocaine Dependence [J].
Batista, Edson Kruger ;
Klauss, Jaisa ;
Fregni, Felipe ;
Nitsche, Michael A. ;
Nakamura-Palacios, Ester Miyuki .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2015, 18 (12) :1-11