Common genetic risk factors of venous thromboembolism in Western and Asian populations

被引：15

作者：

Huang, S. S. ^{[1
]}

Liu, Y. ^{[2
]}

Jing, Z. C. ^{[3
,4
]}

Wang, X. J. ^{[3
,4
]}

Mao, Y. M. ^{[1
]}

机构：

[1] Henan Univ Sci & Technol, Dept Resp Med, Affiliated Hosp 1, Luoyang, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Nucl Med, Zhengzhou 450052, Peoples R China

[3] Chinese Acad Med Sci, FuWai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2016年 / 15卷 / 01期

关键词：

Venous thromboembolism; Genetics; DNA; Asian population; Genome-wide association study; FACTOR-V-LEIDEN; DEEP-VEIN THROMBOSIS; PROTEIN-S DEFICIENCY; ANTITHROMBIN CAMBRIDGE-II; GENOME-WIDE ASSOCIATION; C ANTICOAGULANT SYSTEM; ABO BLOOD-GROUP; CHINESE POPULATION; PROTHROMBIN GENE; RACIAL-DIFFERENCES;

D O I：

10.4238/gmr.15017644

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Venous thromboembolism (VTE) is a multifactorial disorder involving both acquired and genetic risk factors. The common genetic factors in Western populations have been studied and reported for several decades, while studies on Asian populations are relatively scarce. Evidence suggests that the prevalence and genetic risk factors of VTE vary significantly among ethnic populations. In this review, we summarize the common genetic risk factors of VTE in both Western and Asian populations. In addition to the development of DNA sequencing technology, genome-wide association studies have many advantages and are becoming more important in identifying new genetic risk factors and susceptible loci. They can therefore help in the prediction and prevention of VTE.

引用

页数：11

共 57 条

[1]

Angchaisuksiri P, 2000, AM J HEMATOL, V65, P119, DOI 10.1002/1096-8652(200010)65:2<119::AID-AJH5>3.3.CO

[2]

2-#

[3] MUTATION IN BLOOD-COAGULATION FACTOR-V ASSOCIATED WITH RESISTANCE TO ACTIVATED PROTEIN-C [J].

BERTINA, RM ;

KOELEMAN, BPC ;

KOSTER, T ;

ROSENDAAL, FR ;

DIRVEN, RJ ;

DERONDE, H ;

VANDERVELDEN, PA ;

REITSMA, PH .

NATURE, 1994, 369 (6475) :64-67

[4] Gene variants associated with deep vein thrombosis [J].

Bezemer, Irene D. ;

Bare, Lance A. ;

Doggen, Carine J. M. ;

Arellano, Andre R. ;

Tong, Carmen ;

Rowland, Charles M. ;

Catanese, Joseph ;

Young, Bradford A. ;

Reitsma, Pieter H. ;

Devlin, James J. ;

Rosendaal, Frits R. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (11) :1306-1314

[5] Influence of proband's characteristics on the risk for venous thromboembolism in relatives with factor V Leiden or prothrombin G20210A polymorphisms [J].

Bucciarelli, Paolo ;

De Stefano, Valerio ;

Passamonti, Serena M. ;

Tormene, Daniela ;

Legnani, Cristina ;

Rossi, Elena ;

Castaman, Giancarlo ;

Simioni, Paolo ;

Cini, Michela ;

Martinelli, Ida .

BLOOD, 2013, 122 (15) :2555-2561

[6] Thrombophilia, clinical factors, and recurrent venous thrombotic events [J].

Christiansen, SC ;

Cannegieter, SC ;

Koster, T ;

Vandenbroucke, JP ;

Rosendaal, FR .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (19) :2352-2361

[7] ABO Blood Group and von Willebrand Factor Levels Partially Explained the Incomplete Penetrance of Congenital Thrombophilia [J].

Cohen, William ;

Castelli, Christel ;

Alessi, Marie-Christine ;

Aillaud, Marie-Francoise ;

Bouvet, Sophie ;

Saut, Noemie ;

Brunet, Dominique ;

Barthet, Marie-Christine ;

Tregouet, David-Alexandre ;

Lavigne, Geraldine ;

Morange, Pierre-Emmanuel .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (08) :2021-2028

[8] RECURRENT VENOUS THROMBOEMBOLISM IN PATIENTS WITH A PARTIAL DEFICIENCY OF PROTEIN-S [J].

COMP, PC ;

ESMON, CT .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (24) :1525-1528

[9] Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis [J].

Corral, Javier ;

Hernandez-Espinosa, David ;

Soria, Jose Manual ;

Gonzalez-Conejero, Rocio ;

Ordonez, Adriana ;

Gonzalez-Porras, Jose Ramon ;

Perez-Ceballos, Elena ;

Lecumberri, Ramon ;

Sanchez, Ignacio ;

Roldan, Vanessa ;

Mateo, Jose ;

Minano, Antonia ;

Gonzalez, Marcos ;

Alberca, Ignacio ;

Fontcuberta, Jordi ;

Vicente, Vicente .

BLOOD, 2007, 109 (10) :4258-4263

[10] Regulation of blood coagulation by the protein C anticoagulant pathway -: Novel insights into structure-function relationships and molecular recognition [J].

Dahlbäck, B ;

Villoutreix, BO .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (07) :1311-1320

← 1 2 3 4 5 6 →