The role of formins in filopodia formation

被引：129

作者：

Mellor, Harry ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2010年 / 1803卷 / 02期

关键词：

Actin; Cytoskeleton; Formin; Filopodia; Cell migration; DIAPHANOUS-RELATED FORMIN; WISKOTT-ALDRICH-SYNDROME; VASODILATOR-STIMULATED PHOSPHOPROTEIN; DROSOPHILA DORSAL CLOSURE; MISSING-IN-METASTASIS; FILAMENT BARBED ENDS; ACTIN-BASED MOTILITY; MYOSIN-X; GROWTH CONES; ENA/VASP PROTEINS;

D O I：

10.1016/j.bbamcr.2008.12.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Filopodia are highly dynamic cell-surface protrusions used by cells to sense their external environment. At the core of the filopodium is a bundle of actin filaments. These give form to the filopodia and also drive the cycle of elongation and retraction. Recent studies have shown that two very different actin nucleating proteins control the formation of filopodial actin filaments - Arp2/3 and Formins. Although the actin filaments produced by these two nucleators have very different structures and properties, recent work has begun to piece together evidence for co-operation between Arp2/3 and formins in filopodia formation, leading to a deeper understanding of these sensory organelles. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：191 / 200

页数：10

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