Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis

被引：7

作者：

Ipseiz, Natacha ^{[1
,2
,3
]}

Scholtysek, Carina ^{[1
,2
,3
]}

Culemann, Stephan ^{[1
,2
,3
]}

Kroenke, Gerhard ^{[1
,2
,3
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Internal Med 3, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Inst Clin Immunol, D-91054 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, D-91054 Erlangen, Germany

来源：

SWISS MEDICAL WEEKLY | 2014年 / 144卷

关键词：

inflammation; nuclear receptors; bone; macrophages; osteoblasts; osteoclasts; arthritis; PROLIFERATOR-ACTIVATED-RECEPTOR; NF-KAPPA-B; LIVER-X-RECEPTORS; COLLAGEN-INDUCED ARTHRITIS; ALLERGIC CONTACT-DERMATITIS; PPAR-GAMMA AGONISTS; DENDRITIC CELL-FUNCTION; NUCLEAR RECEPTORS; GENE-EXPRESSION; BONE-MARROW;

D O I：

10.4414/smw.2014.14055

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of inflammation and immunity and likewise control skeletal homeostasis. These properties render them attractive targets for the therapy of various inflammatory and autoimmune diseases affecting the musculoskeletal system. This review summarises the current knowledge on the role of these families of receptors during innate and adaptive immunity as well as during the control of bone turnover and discuss the potential use of targeting these molecules during the treatment of chronic diseases such as osteoarthritis, rheumatoid arthritis and osteoporosis.

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页数：12

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