A coumarin based azo-phenol ligand as efficient fluorescent "OFF-ON-OFF" chemosensor for sequential detection of Mg2+ and F-: Application in live cell imaging and as molecular logic gate

被引：34

作者：

Gharami, Saswati ^{[1
]}

Sarkar, Deblina ^{[2
]}

Ghosh, Paramita ^{[2
]}

Acharyya, Samik ^{[1
]}

Aich, Krishnendu ^{[1
]}

Murmu, Nabendu ^{[2
]}

Mondal, Tapan Kumar ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, India

[2] Chittaranjan Natl Canc Inst, Dept Signal Transduct & Biogenis Amines STBA, Kolkata 700026, India

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2017年 / 253卷

关键词：

Coumarin based azo-phenol ligand; Fluorescence turn-on chemosensor for; Mg2+; Detection of F-; A549 lung cancer cell line; Live cell imaging; DFT calculation; DENSITY-FUNCTIONAL THEORY; SELECTIVE DETECTION; SCHIFF-BASE; EXCITATION-ENERGIES; MAGNESIUM; FLUORIDE; SENSOR; PROBE; APPROXIMATION; DERIVATIVES;

D O I：

10.1016/j.snb.2017.06.148

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel coumarin based azo-phenol ligand (H2L) has been synthesized and characterized by several spectroscopic techniques. An almost 16 fold enhancement of emission intensity has been observed upon gradual addition of Mg2+ to H2L in DMSO:H2O (1:5 v/v) medium while it has no significant effect in emission intensity even in presence of other metal ions. The emission intensity of L-Mg2+ complex has almost quenched on gradual addition of F- to it. The limit of detection for both Mg2+ and F- are of 10(-8) mu M order, hence the newly developed chemosensor is highly efficient in detecting Mg2+ and F- in very minute levels. The chemosensor can even detect Mg2+ in the intracellular region of human lung cancer cells (A549 cells). (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：317 / 325

页数：9

共 57 条

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