Bcl-2-related genes in lymphoid neoplasia

被引：28
作者：
Wei, MC
机构：
[1] Harvard Univ, Sch Med, Childrens Hosp, Dept Med, Boston, MA 02125 USA
[2] Boston Univ, Sch Med, Dept Pediat, Boston Med Ctr, Boston, MA 02118 USA
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2004年 / 80卷 / 03期
关键词：
Bcl-2; apoptosis; leukemia; lymphoma;
D O I：
10.1532/IJH97.04110
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The proto-oncogene BCL-2 was discovered with the cloning of the t(14;18) chromosomal translocation responsible for human follicular lymphoma. Since then other members of the Bcl-2 family of cell death regulators have been identified and their roles in cell death, normal lymphoid development, and lymphoid neoplasia have been characterized. Bcl-2 family members are important in tumor initiation, progression, and response to chemotherapy, and altered expression levels of various members serve as prognostic markers in many lymphoid malignancies. There are promising cancer therapeutics now targeted at members of the Bcl-2 family. (C) 2004 The Japanese Society of Hematology.
引用
收藏
页码：205 / 209
页数：5
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