Copper-Catalyzed Annulation of 2-Formylazoles with o-Aminoiodoarenes

被引：70

作者：

Reeves, Jonathan T. ^{[1
]}

Fandrick, Daniel R. ^{[1
]}

Tan, Zhulin ^{[1
]}

Song, Jinhua J. ^{[1
]}

Lee, Heewon ^{[1
]}

Yee, Nathan K. ^{[1
]}

Senanayake, Chris H. ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 03期

关键词：

BIOLOGICAL EVALUATION; N-ARYLATION; DERIVATIVES;

D O I：

10.1021/jo9025644

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of catalytic CuI and sparteine, 2-formyl-pyrroles can be annulated with o-aminoiodoarenes to give Substituted pyrrolo[1,2-a]quinoxalines and related heterocycles. The reaction also works for annulation of 2-formylindoles, 2-formylimidazole, 2-formylbenzimidazole, and a 3-formylpyrazole.

引用

页码：992 / 994

页数：3

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