Progress in the function of D-serine in mammalian central nervous system

被引：0
作者：
Yang, HB [1 ]
Yuan, JG
Peng, XZ
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China
[2] Peking Union Med Coll, Natl Lab Med Biol, Beijing 100005, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2003年 / 30卷 / 06期
关键词：
D-serine; serine racemase; NMDA receptor;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The regional high distribution of D-serine in mammalian central nervous system is consistent with that of N-methyl-D-aspartate receptor. D-serine is synthesized by a glial serine racemase, a novel enzyme converting L- to D-serine in mammalian brain. D-amino acid oxidase (DAO) is a flavoenzyme that catalyzes D-amino acids. D-serine as a glia-derived transmitter not only questions the basic ideas about "neurotransmitter" but also offers a novel way to treat some brain disorders as both over-stimulation and down regulation of NMDA receptors has been implicated in a large number of acute and chronic neurodiseases.
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收藏
页码：852 / 854
页数：3
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