A case of nasal septal abscess caused by medication related osteonecrosis in breast cancer patient

被引：6

作者：

Maeda, Mayuka ^{[1
]}

Matsunobu, Takeshi ^{[1
,2
]}

Kurioka, Takaomi ^{[1
]}

Kurita, Akihiro ^{[3
]}

Shiotani, Akihiro ^{[1
]}

机构：

[1] Natl Def Med Coll, Dept Otolaryngol Head & Neck Surg, Namiki 3-2, Tokorozawa, Saitama 3598513, Japan

[2] New Tokyo Hosp, Dept Otolaryngol, Wanagaya 1271, Matsudo, Chiba, Japan

[3] Nisseki Hosp, Dept Otolaryngol, Chuo Ku, Kamiochiai 8-3-33, Saitama, Japan

来源：

AURIS NASUS LARYNX | 2016年 / 43卷 / 01期

关键词：

MRONJ; Nasal septal abscess; Bisphosphonate; Osteonecrosis; RISK-FACTORS; BISPHOSPHONATES; JAWS;

D O I：

10.1016/j.anl.2015.04.006

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Antiresorptive drugs have been widely used to treat patients with hypercalcemia caused by malignancy, bone metastasis, multiple myeloma, and osteoporosis. However, it is well known that antiresorptive drugs can cause osteonecrosis of the jaw (ONJ). Herein, we report a rare case of nasal septal abscess caused by medication related osteonecrosis of the jaw (MRONJ) in a breast cancer patient. A 69-year-old woman was referred to our clinic for evaluation of nasal obstruction. Physical examination revealed a cherry-like swelling of the nasal mucosa emanating from the septum that obstructed both nasal cavities and a fistulous tract showing pus discharge after extraction of the bilateral maxillary central incisors (MCI) and the right maxillary lateral incisor (MLI). Computed tomography and. panoramic radiography revealed extensive osteonecrosis of the maxilla and swelling of the nasal mucosa. The clinical diagnosis was nasal septal abscess caused by osteonecrosis of the maxilla. Surgical procedure was undertaken for this case. An indwelling drain was placed in the oral cavity, and sequestrectomy was performed with incision and drainage of the anterior portion of left nasal septum. The patient was doing well at the 7-month follow-up. The patient had a medical history of breast cancer with bone, lung, liver metastases, and had received intravenous bisphosphonate, which is one of the antiresorptive medicines, over the past 4 years. We suspect that this history played an important role in MRONJ induced nasal septal abscess. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：93 / 96

页数：4

共 14 条

[11] Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases [J].

Saad, F. ;

Brown, J. E. ;

Van Poznak, C. ;

Ibrahim, T. ;

Stemmer, S. M. ;

Stopeck, A. T. ;

Diel, I. J. ;

Takahashi, S. ;

Shore, N. ;

Henry, D. H. ;

Barrios, C. H. ;

Facon, T. ;

Senecal, F. ;

Fizazi, K. ;

Zhou, L. ;

Daniels, A. ;

Carriere, P. ;

Dansey, R. .

ANNALS OF ONCOLOGY, 2012, 23 (05) :1341-1347

[12]

Shimahara M, 2007, JPN J ORAL MAXILLOFA, V53, P594

[13]

Vescovi P, 2006, J ORAL MAXIL SURG, V64, P1460, DOI 10.1016/j.joms.2006.05.042

[14] Systematic review: Bisphosphonates and osteonecrosis of the jaws [J].

Woo, Sook-Bin ;

Hellstein, John W. ;

Kalmar, John R. .

ANNALS OF INTERNAL MEDICINE, 2006, 144 (10) :753-761

← 1 2 →