B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial

被引:47
作者
Almeida, Osvaldo P. [1 ,2 ,3 ]
Ford, Andrew H. [1 ,2 ,3 ]
Hirani, Varsha [1 ,2 ]
Singh, Vash [3 ]
vanBockxmeer, Frank M. [4 ]
McCaul, Kieran [1 ]
Flicker, Leon [2 ,5 ,6 ]
机构
[1] WA Ctr Hlth & Ageing, Med Res Ctr, Perth, WA, Australia
[2] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
[3] Royal Perth Hosp, Dept Psychiat, Perth, WA 6001, Australia
[4] Royal Perth Hosp, PathWest Lab Med WA, Dept Clin Biochem, Perth, WA 6001, Australia
[5] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia
[6] Royal Perth Hosp, Dept Geriatr Med, Perth, WA 6001, Australia
基金
英国医学研究理事会;
关键词
FOLIC-ACID; DEPRESSIVE SYMPTOMS; SERUM FOLATE; MAJOR DEPRESSION; TERM OUTCOMES; HOMOCYSTEINE; AUGMENTATION; ASSOCIATION; VALIDATION; DEFICIENCY;
D O I
10.1192/bjp.bp.114.145177
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Depression is common and the efficacy of antidepressants is suboptimal. High plasma homocysteine has been consistently associated with depression, and treatment with certain B vitamins demonstrably reduces its concentration. Aims To determine whether vitamins B-6, B-12 and folic acid enhance response to antidepressant treatment over 52 weeks. Method Randomised, double-blind, placebo-controlled trial of citalopram (20-40 g) together with 0.5 mg of vitamin B12, 2 mg of folic acid and 25 mg of vitamin B6 for 52 weeks (Australian and New Zealand Clinical Trials Registry: 12609000256279). Participants were community-dwelling adults aged 50 years or over with DSM-IV-TR major depression. We measured severity of symptoms with the Montgomery-Asberg Depression Rating Scale (MADRS). The primary outcome was remission of the depressive episode after 12, 26 and 52 weeks. Secondary outcomes included reduction of MADRS scores over time and relapse of major depression after recovery by week 12. Results In total, 153 people were randomised (76 placebo, 77 vitamins). Remission of symptoms was achieved by 78.1 and 79.4% of participants treated with placebo and vitamins by week 12 (P=0.840), by 76.5 and 85.3% at week 26 and 75.8 and 85.5% at week 52 (effect of intervention over 52 weeks: odds ratio (OR)=2.49, 95% Cl 1.12-5.51). Group differences in MADRS scores over time were not significant (P=0.739). The risk of subsequent relapse among those who had achieved remission of symptoms at week 12 was lower in the vitamins than placebo group (OR=0.33, 95% Cl 0.12-0.94). Conclusions B vitamins did not increase the 12-week efficacy of antidepressant treatment, but enhanced and sustained antidepressant response over 1 year. Replication of these findings would mandate that treatment guidelines adopt the adjunctive use of B vitamins as a safe and inexpensive strategy to manage major depression in middle-aged and older adults.
引用
收藏
页码:450 / 457
页数:8
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