A comprehensive review of paediatric low-grade diffuse glioma: pathology, molecular genetics and treatment

被引：41

作者：

Ryall, Scott ^{[1
,2
]}

Tabori, Uri ^{[1
,3
]}

Hawkins, Cynthia ^{[1
,2
,4
]}

机构：

[1] Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Fac Med, Toronto, ON, Canada

[3] Hosp Sick Children, Div Haematol & Oncol, Toronto, ON, Canada

[4] Hosp Sick Children, Div Pathol, Toronto, ON, Canada

来源：

BRAIN TUMOR PATHOLOGY | 2017年 / 34卷 / 02期

关键词：

Paediatric; Low-grade diffuse glioma; Histology; Incidence; Molecular events; Clinical trials; CENTRAL-NERVOUS-SYSTEM; RECEPTOR TYROSINE KINASES; INTRINSIC PONTINE GLIOMA; MAPK PATHWAY ACTIVATION; TUMOR-SUPPRESSOR GENE; CODON; 132; MUTATION; IDH2; MUTATIONS; PILOCYTIC ASTROCYTOMA; HOTSPOT MUTATIONS; GENOMIC ANALYSIS;

D O I：

10.1007/s10014-017-0282-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gliomas are the most common central nervous system neoplasms affecting children and can be both high- and low-grade. Paediatric low-grade glioma may be either World Health Organization grade I or grade II. Despite being classified as grade II diffuse astrocytoma, these neoplasms arising in children are distinct clinically and molecularly from their adult counterparts. They do not tend to progress to higher grade lesions and only rarely harbour an IDH mutation. Here, we review the clinical, histologic and molecular features of paediatric grade II diffuse glioma, highlighting their diagnostic criteria, prevalence across brain locations, their most common molecular features and how to test for them, and lastly the current status of therapeutic options available for their treatment.

引用

页码：51 / 61

页数：11

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