Microenvironmental regulation of tumour angiogenesis

被引：1439

作者：

de Palma, Michele ^{[1
]}

Biziato, Daniela ^{[1
]}

Petrova, Tatiana V. ^{[2
,3
,4
]}

机构：

[1] Ecole Polytech Fed Lausanne, Sch Life Sci, Swiss Inst Expt Canc Res ISREC, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne, Ludwig Inst Canc Res, Dept Fundamental Oncol, CH-1066 Lausanne, Switzerland

[3] Univ Lausanne, Div Expt Pathol, CH-1066 Lausanne, Switzerland

[4] Univ Lausanne Hosp, CH-1066 Lausanne, Switzerland

来源：

NATURE REVIEWS CANCER | 2017年 / 17卷 / 08期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

ENDOTHELIAL GROWTH-FACTOR; PANCREATIC-ISLET TUMORS; VESSEL CO-OPTION; ANTIANGIOGENIC THERAPY; MYELOID CELLS; BREAST-CANCER; EXTRACELLULAR VESICLES; OXIDATIVE STRESS; BLOOD-VESSELS; MAST-CELLS;

D O I：

10.1038/nrc.2017.51

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cells in concert with a variety of tumour-associated stromal cells and their bioactive products, which encompass cytokines and growth factors, the extracellular matrix and secreted microvesicles. In this Review, we discuss the extrinsic regulation of angiogenesis by the tumour microenvironment, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies.

引用

页码：457 / 474

页数：18

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