A novel pH-responsive interpolyelectrolyte hydrogel complex for the oral delivery of levodopa. Part I. IPEC modeling and synthesis

被引：7

作者：

Ngwuluka, Ndidi C. ^{[1
]}

Choonara, Yahya E. ^{[1
]}

Kumar, Pradeep ^{[1
]}

du Toit, Lisa C. ^{[1
]}

Khan, Riaz A. ^{[2
]}

Pillay, Viness ^{[1
]}

机构：

[1] Univ Witwatersrand, Dept Pharm & Pharmacol, Wits Adv Drug Delivery Platform Res Unit, Sch Therapeut Sci,Fac Hlth Sci, ZA-2193 Parktown, South Africa

[2] Manav Rachna Int Univ, Dept Chem, Faridabad, Haryana, India

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2015年 / 103卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

interpolyelectrolyte complex; methacrylic acid copolymer; sodium carboxymethylcellulose; hydrogel; controlled release; drug delivery; levodopa molecular mechanics; INTERPOLYMER COMPLEXES; VIVO EVALUATION; RELEASE; CHITOSAN;

D O I：

10.1002/jbm.a.35259

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study was undertaken to synthesize an interpolyelectrolyte complex (IPEC) of polymethacrylate (E100) and sodium carboxymethylcellulose (NaCMC) to form a polymeric hydrogel material for application in specialized oral drug delivery of sensitive levodopa. Computational modeling was employed to proffer insight into the interactions between the polymers. In addition, the reactional profile of NaCMC and polymethacrylate was elucidated using molecular mechanics energy relationships (MMER) and molecular dynamics simulations (MDS) by exploring the spatial disposition of NaCMC and E100 with respect to each other. Computational modeling revealed that the formation of the IPEC was due to strong ionic associations, hydrogen bonding, and hydrophilic interactions. The computational results corroborated well with the experimental and the analytical data. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1077-1084, 2015.

引用

页码：1077 / 1084

页数：8

共 23 条

[1] Design and in vitro/in vivo evaluation of novel nicorandil extended release matrix tablets based on hydrophilic interpolymer complexes and a hydrophobic waxy polymer [J].